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March 04, 2021 conference-paper Aachen paper

The relation between pre-existing plaque burden and strut coverage after DES implantation in familial hypercholesterolemia swine: an OCT study

Diagnostic and Therapeutic Applications of Light in Cardiology, pp. 13

DOI: 10.1117/12.2582723 OpenAlex

Abstract

Neointima (NI) healing after implantation of drug-eluting coronary stents (DES) is often preclinically evaluated in healthy swine coronary models, which only allow limited conclusions. In this study, DES were implanted in an adult familial hypercholesterolemia (FH) swine model in order to better reproduce the range of NI responses that are seen in humans. Serial OCT imaging was performed before and after stenting, and at 28 days FU. The NI response showed a wide spectrum of strut coverage types. Higher percentages baseline plaque burden resulted in more uncovered struts and heterogeneous patterns of strut coverage, uniquely showing similarities to human responses.

Authors 15

  1. Francesca Razzi

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  2. Jouke Dijkstra Aachen Leiden Univ. Medical Ctr

    Leiden University Medical Center

    Affiliation as printed

    Leiden Univ. Medical Ctr. (Netherlands)

  3. Karen Th. Witberg

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  4. Jurgen M.R. Ligthart

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  5. Sharad Ramlal

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  6. Mathijs Stam

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  7. Ilona Krabbendam‐Peters

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  8. Ayla Hoogendoorn

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  9. Dirk-Jan Duncker

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  10. Jan van Esch

    Delft University of Technology

    Affiliation as printed

    Technische Univ. Delft (Netherlands)

  11. Jolanda J. Wentzel

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

  12. Gijs van Soest
  13. Volkert van Steijn

    Delft University of Technology

    Affiliation as printed

    Technische Univ. Delft (Netherlands)

  14. Evelyn S. Regar

    Ludwig-Maximilians-Universität München

    Affiliation as printed

    Ludwig-Maximilians-Univ München (Germany)

  15. Heleen M.M. van Beusekom

    Erasmus MC

    Affiliation as printed

    Erasmus MC (Netherlands)

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