Quantitative sodium imaging using ultra‐high field magnetic resonance imaging in patients with Alzheimer's disease
Alzheimer s & Dementia, vol. 16
Abstract
Abstract Background In Alzheimer’s disease (AD), energy deficit is suspected to occur before clinical symptoms arise. Therefore, neuroimaging methods sensitive to metabolic alterations are attractive to improve diagnostics, therapeutics and follow‐ups of AD patients. An indirect measure of deficient Na+/K+‐ATPase‐activity during neurodegeneration is provided by the tissue sodium concentration (TSC) measured by Sodium‐(23Na)‐MRI. Method 16 patients (7 Male, 71.7±8 years) diagnosed with AD (MoCA 15.1±7) were recruited from Ste. Anne Hospital in Paris as well as 16 cognitively healthy age‐matched control subjects (7 Male, 69±3.1 years; MoCA 28.1±1.8). Each subject underwent 23Na and 1H MRI examinations at the 7T MRI scanner (Siemens) at Neurospin, CEA. A dual‐resonance 1H/23Na volume coil (Rapid Biomedical) was used for a 23Na MRI protocol acquiring ultra‐short echo‐time images (3mm isotropic resolution) at two flip‐angles (a1=25º/a2=55º) (Coste et al., 2019). Briefly, processing steps comprised image reconstruction, denoising, motion‐ and B1‐inhomogeneities‐corrections, and a calibration step using 4 external references. Individual TSC maps were co‐registered to their T1‐weighted anatomical reference (MP2RAGE, 750 µm isotropic resolution) and a partial‐volume‐effect correction (Thomas et al., 2016) was implemented to limit the influence of sodium from cerebrospinal fluid. Anatomical and TSC images were normalized to the OASIS template using ANTs. A parameter free permutation analysis was performed voxel‐wise on normalized TSC images and on the LogJacobian of the deformation fields. After, region‐of‐interest‐analyses on hippocampus from VolBrain‐Atlas followed. Result The voxel‐based analysis showed significant widespread increases in TSC of AD patients, particularly in parietal, temporal and frontal regions. Interestingly, the observed TSC changes were located in areas not directly associated to significant structural changes (Fig 1). Furthermore, TSC in the hippocampus was found significantly higher in AD than in controls (42.9±4.3mmol/l; 35.8±3.9mmol/l; Wilcoxon‐rank‐sum; p=0.00015, z=3.8) and was correlated, after controlling for age, with both the MoCA‐scores (r=‐0.62; p=0.0002) and hippocampal volumes (r=‐0.39; p=0.032). Conclusion High‐field quantitative 23Na MRI in AD shows increased TSC values across a wide range of brain regions. These results may provide a deeper insight into metabolic alterations occurring during neurodegeneration. 23Na MRI could therefore serve as a useful tool to characterize disease progression or the impact of therapeutic intervention.
Authors 11
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Forschungszentrum Jülich · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Institut des Sciences du Vivant Frédéric Joliot · Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
JARA‐BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen University Aachen Germany
NeuroSpin Frédéric Joliot Life Sciences Institute, CEA Gif‐sur‐Yvette France
RWTH Aachen University Aachen Germany
RWTH Aachen University Aachen Germany
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Lyon 1 Université · Centre National de la Recherche Scientifique · Inserm · Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé · Université Jean Monnet · Institut National des Sciences Appliquées de Lyon · Université Jean Monnet
Affiliation as printed
CREATIS, CNRS UMR 5220 – INSERM U1206 – Université Lyon 1 – INSA Lyon Université Jean Monnet Saint‐Etienne Lyon France
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Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Institut des Sciences du Vivant Frédéric Joliot
Affiliation as printed
NeuroSpin Frédéric Joliot Life Sciences Institute, CEA Gif‐sur‐Yvette France
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Centre National de la Recherche Scientifique · Inserm · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Université Paris-Saclay · CEA Paris-Saclay - Etablissement de Saclay · Sorbonne Paris Cité · Centre Hospitalier Sainte-Anne · Université Paris Descartes · Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay
Affiliation as printed
Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité Centre Hospitalier Sainte Anne Paris France
Université Paris‐Saclay CEA, CNRS, Inserm, BioMaps Orsay France
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Jörg Bernhard Schulz Aachen
Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
JARA‐BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen University Aachen Germany
RWTH Aachen University Aachen Germany
RWTH Aachen University Aachen Germany
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Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Institut des Sciences du Vivant Frédéric Joliot
Affiliation as printed
NeuroSpin Frédéric Joliot Life Sciences Institute, CEA Gif‐sur‐Yvette France
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Centre National de la Recherche Scientifique · Inserm · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Université Paris-Saclay · CEA Paris-Saclay - Etablissement de Saclay · Sorbonne Paris Cité · Centre Hospitalier Sainte-Anne · Université Paris Descartes · Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay
Affiliation as printed
Neurology of Memory and Language Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne Paris France
Université Paris‐Saclay CEA, CNRS, Inserm, BioMaps Orsay France
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Centre National de la Recherche Scientifique · Inserm · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Université Paris-Saclay · CEA Paris-Saclay - Etablissement de Saclay · Institut des Sciences du Vivant Frédéric Joliot · Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay
Affiliation as printed
NeuroSpin Frédéric Joliot Life Sciences Institute, CEA Gif‐sur‐Yvette France
Université Paris‐Saclay CEA, CNRS, Inserm, BioMaps Orsay France
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Kathrin Reetz Aachen
Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
JARA‐BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen University Aachen Germany
RWTH Aachen University Aachen Germany
RWTH Aachen University Aachen Germany
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Sandro Romanzetti Aachen
Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
JARA‐BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen University Aachen Germany
RWTH Aachen University Aachen Germany
RWTH Aachen University Aachen Germany
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Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Institut des Sciences du Vivant Frédéric Joliot
Affiliation as printed
NeuroSpin Frédéric Joliot Life Sciences Institute, CEA Gif‐sur‐Yvette France
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