Trabecular Bone Assessment Using Magnetic-Resonance Imaging: A Pilot Study

International Journal of Environmental Research and Public Health, vol. 17, pp. 9282

Abstract

The aim of this study was to assess trabecular bone morphology via magnetic-resonance imaging (MRI) using microcomputed tomography (µCT) as the control group. Porcine bone samples were scanned with T1-weighted turbo spin echo sequence imaging, using TR 25 ms, TE 3.5 ms, FOV 100 × 100 × 90, voxel size 0.22 × 0.22 × 0.50 mm, and scan time of 11:18. µCT was used as the control group with 80 kV, 125 mA, and a voxel size of 16 µm. The trabecular bone was segmented on the basis of a reference threshold value and morphological parameters. Bone volume (BV), Bone-volume fraction (BvTv), Bone specific surface (BsBv), trabecular thickness (TbTh), and trabecular separation (TbSp) were evaluated. Paired t-test and Pearson correlation test were performed at p = 0.05. MRI overestimated BV, BvTv, TbTh, and TbSp values. BsBv was the only parameter that was underestimated by MRI. High statistical correlation (r = 0.826; p < 0.05) was found for BV measurements. Within the limitations of this study, MRI overestimated trabecular bone parameters, but with a statistically significant fixed linear offset.

Authors 6

1. Lauren Oliveira Lima Bohner corresponding

   Universidade de São Paulo · University Hospital Münster

   Affiliation as printed

   Department of Cranio-Maxillofacial Surgery, University Hospital Muenster, 48149 Muenster, Germany

   Department of Prosthodontics, School of Dentistry, University of São Paulo, São Paulo 0508-000, Brazil

2. Pedro Tortamano

   Universidade de São Paulo

   Affiliation as printed

   Department of Prosthodontics, School of Dentistry, University of São Paulo, São Paulo 0508-000, Brazil

3. Norbert Meier

   University of Münster · University Hospital Münster

   Affiliation as printed

   Institute of Clinical Radiology, University Clinics Muenster, 48149 Muenster, Germany

4. Felix Gremse Aachen Department of Experimental Molecular Imaging

   RWTH Aachen University

   Affiliation as printed

   Department of Experimental Molecular Imaging, Helmholtz Institute, RWTH Aachen University, 52074 Aachen, Germany

5. Johannes Kleinheinz

   University Hospital Münster

   Affiliation as printed

   Department of Cranio-Maxillofacial Surgery, University Hospital Muenster, 48149 Muenster, Germany

6. Marcel René Hanisch

   University Hospital Münster

   Affiliation as printed

   Department of Cranio-Maxillofacial Surgery, University Hospital Muenster, 48149 Muenster, Germany