Hippocampal-cortical encoding activity predicts the precision of episodic memory

bioRxiv (Cold Spring Harbor Laboratory)

Abstract

Abstract Our recollections of past experiences can vary both in the number of specific event details accessible from memory and the precision with which such details are reconstructed. Prior neuroimaging evidence suggests the success and precision of episodic recollection to rely on distinct neural substrates during memory retrieval . In contrast, the specific encoding mechanisms supporting later memory precision, and whether they differ from those underlying successful memory formation in general, are currently unknown. Here, we combined continuous measures of memory retrieval with model-based analyses of behavioural and neuroimaging data to tease apart the encoding correlates of successful memory formation and mnemonic precision. In the MRI scanner, participants encoded object-scene displays, and later reconstructed features of studied objects using a continuous scale. We observed overlapping encoding activity in inferior prefrontal and posterior perceptual regions to predict both which object features were later remembered versus forgotten, and the precision with which they were reconstructed from memory. In contrast, hippocampal encoding activity significantly predicted the precision, but not overall success, of subsequent memory retrieval. The current results identify a hippocampal-cortical encoding basis for episodic memory precision, and suggest a contribution of shared cortical encoding mechanisms to the formation of both accessible and precise memory representations.

Authors 3

1. Saana M. Korkki corresponding

   University of Cambridge

   Affiliation as printed

   Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom

2. Franziska R. Richter Aachen Cognitive Psychology Unit Institute of Psychology, University of Leiden

   Leiden University

   Affiliation as printed

   Cognitive Psychology Unit, Institute of Psychology, University of Leiden, Leiden 2333 AK, Netherlands

   Cognitive Psychology Unit, Institute of Psychology, University of Leiden, Leiden 333 AK, Netherlands

3. Jon S. Simons corresponding

   University of Cambridge

   Affiliation as printed

   Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom