Novelty Processing Depends on Medial Temporal Lobe Structures

bioRxiv (Cold Spring Harbor Laboratory)

Abstract

Abstract Objectives The goal of the present study was to identify the role of the medial temporal lobe (MTL) in the detection and later processing of novelty stimuli. Methods Twenty-one epilepsy patients with unilateral MTL resection (10 left-sided; 11 right-sided) performed an adapted visual novelty oddball task. In this task two streams of stimuli were presented on the left and right of fixation while the patients’ electroencephalogram was measured. Patients responded to infrequent target stimuli, while ignoring frequent standard, and infrequent novel stimuli that could appear either contra- or ipsilateral to the resected side. Results Novelty detection, as indexed by the N2 ERP component elicited by novels, was not affected by the MTL resections. Later processing of novels, however, as indexed by the novelty P3 ERP component, was reduced for novels presented contra-versus ipsilateral to the resected side. Target processing, as indexed by the P3b, was unaffected. Conclusions The current results suggest that MTL structures play a role in novelty processing, but that the novelty signal may originate from a distinct neural source.

Authors 6

1. Judith Schomaker corresponding Aachen Faculty of Social and Behavioural Sciences

   Leiden University

   Affiliation as printed

   Faculty of Social and Behavioural Sciences, Leiden University, the Netherlands

2. M.M.E. Grouls

   Altrecht GGZ

   Affiliation as printed

   GGZ Altrecht, Vesalius Centre for Neuropsychiatry, Woerden, the Netherlands

3. Elias M. B. Rau

   Ruhr University Bochum

   Affiliation as printed

   Department of Psychology, Ruhr University Bochum, Germany

4. Marc P. H. Hendriks

   Radboud University Nijmegen · Kempenhaeghe · Donders Institute for Brain, Cognition and Behaviour

   Affiliation as printed

   Academic Centre for Epileptology, Kempenhaeghe, Heeze, the Netherlands

   Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen, the Netherlands

5. Albert Colon

   Kempenhaeghe

   Affiliation as printed

   Academic Centre for Epileptology, Kempenhaeghe, Heeze, the Netherlands

6. Martijn Meeter

   Vrije Universiteit Amsterdam

   Affiliation as printed

   Department of Education, VU University Amsterdam, the Netherlands