Coagulation factor VIII, white matter hyperintensities and cognitive function: Results from the Cardiovascular Health Study
PLoS ONE, vol. 15, pp. e0242062
Abstract
OBJECTIVE: To investigate the relationship between high FVIII clotting activity (FVIII:C), MRI-defined white matter hyperintensities (WMH) and cognitive function over time. METHODS: Data from the population-based Cardiovascular Health Study (n = 5,888, aged ≥65) were used. FVIII:C was measured in blood samples taken at baseline. WMH burden was assessed on two cranial MRI scans taken roughly 5 years apart. Cognitive function was assessed annually using the Modified Mini-Mental State Examination (3MSE) and Digit Symbol Substitution Test (DSST). We used ordinal logistic regression models adjusted for demographic and cardiovascular factors in cross-sectional and longitudinal WMH analyses, and adjusted linear regression and linear mixed models in the analyses of cognitive function. RESULTS: After adjustment for confounding, higher levels of FVIII:C were not strongly associated with the burden of WMH on the initial MRI scan (OR>p75 = 1.20, 95% CI 0.99-1.45; N = 2,735) nor with WMH burden worsening over time (OR>p75 = 1.18, 95% CI 0.87-1.59; N = 1,527). High FVIII:C showed no strong association with cognitive scores cross-sectionally (3MSE>p75 β = -0.06, 95%CI -0.45 to 0.32, N = 4,005; DSST>p75 β = -0.69, 95%CI -1.52 to 0.13, N = 3,954) or over time (3MSE>p75 β = -0.07,95% CI -0.58 to 0.44, N = 2,764; DSST>p75 β = -0.22, 95% CI -0.97 to 0.53, N = 2,306) after confounding adjustment. INTERPRETATION: The results from this cohort study of older adult participants indicate no strong relationships between higher FVIII:C levels and WMH burden or cognitive function in cross-sectional and longitudinal analyses.
Authors 10
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Jessica Lee Rohmann corresponding
Center for Stroke Research Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Charité -Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany
Charité -Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany
Charité –Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany
Charité –Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany
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Affiliation as printed
Department of Epidemiology, University of Washington, Seattle, WA, United States of America
Department of Neurology, University of Washington, Seattle, WA, United States of America
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Affiliation as printed
Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, United States of America
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Affiliation as printed
Department of Epidemiology, University of Washington, Seattle, WA, United States of America
Department of Family Medicine, University of Washington, Seattle, WA, United States of America
Department of Global Health, University of Washington, Seattle, WA, United States of America
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Affiliation as printed
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, United States of America
Department of Epidemiology, University of Washington, Seattle, WA, United States of America
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Affiliation as printed
Department of Biostatistics, University of Washington, Seattle, WA, United States of America
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Leiden University Medical Center
Affiliation as printed
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
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Affiliation as printed
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, United States of America
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Kaiser Permanente Washington Health Research Institute · University of Washington
Affiliation as printed
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, United States of America
Department of Epidemiology, University of Washington, Seattle, WA, United States of America
Department of Health Services, University of Washington, Seattle, WA, United States of America
Department of Medicine, University of Washington, Seattle, WA, United States of America
Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States of America
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Leiden University Medical Center · Center for Stroke Research Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Charité -Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Charité –Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany
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