Aptamer protective groups tolerate different reagents and reactions for regioselective modification of neomycin B
Organic & Biomolecular Chemistry, vol. 18, pp. 9606–9610
Abstract
The aptameric protective group strategy for the one-step regioselective transformation of aminoglycoside antibiotics was found to be compatible with diverse reagents and reaction conditions. New derivatives of neomycin B were synthesized with regioselectivities of >99%. This result extends the scope of applicability of APGs facilitating access to novel aminoglycoside derivatives.
Authors 2
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Andreas A. Bastian Aachen DWI - Leibniz Institute for Interactive Materials Institute for Technical and Macromolecular Chemistry
RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials
Affiliation as printed
52056 Aachen
DWI – Leibniz Institute for Interactive Materials
Germany
Institute for Technical and Macromolecular Chemistry
RWTH Aachen University
RWTH Aachen University, Institute for Technical and Macromolecular Chemistry, Worringerweg 1, 52074 Aachen, Germany
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Agnieszka Gruszka Aachen DWI - Leibniz Institute for Interactive Materials Institute for Technical and Macromolecular Chemistry
RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials
Affiliation as printed
52056 Aachen
DWI – Leibniz Institute for Interactive Materials
Germany
Institute for Technical and Macromolecular Chemistry
RWTH Aachen University
RWTH Aachen University, Institute for Technical and Macromolecular Chemistry, Worringerweg 1, 52074 Aachen, Germany
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