Ozone injection therapy for intervertebral disc herniation

British Medical Bulletin, vol. 136, pp. 88–106

Abstract

INTRODUCTION: Lumbar disc herniation (LDH) is a common cause of low back pain (LBP). Recently, in the setting of LBP caused by LDH, a growing interest in ozone therapies has been observed. SOURCE OF DATA: Recent published literatures. AREAS OF AGREEMENT: Being low back pain more common in the elderlies, exploring conservative alternatives to the surgical intervention is of especial interest. AREAS OF CONTROVERSY: Efficacy and feasibility of ozone injections for LDH is debated. Several clinical studies showed controversial results, and the true benefit has not yet been clarified. GROWING POINTS: Systematically summarize current evidences, analyze the quantitative available data and investigate the role of percutaneous ozone therapy for LDH. AREAS TIMELY FOR DEVELOPING RESEARCH: Current evidence encourage the use of ozone therapy for LBP from LDH. These conclusions should be interpret in light of the limitations of the present study.

Authors 6

1. Filippo Migliorini Aachen Department of Orthopaedics

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Orthopaedics, RWTH University Clinic Aachen, Aachen, Germany, Pauwelsstraβe 30, 52074 Aachen

2. Nicola Maffulli corresponding

   University of London · University of Salerno · Queen Mary University of London · Mile End Hospital · Keele University

   Affiliation as printed

   Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi (SA), Italy

   Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine, Mile End Hospital, 275 Bancroft Road, London E1 4DG, England

   School of Pharmacy and Bioengineering, Keele University School of Medicine, Thornburrow Drive, Stoke on Trent, England

3. Jörg Eschweiler Aachen Department of Orthopaedics

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Orthopaedics, RWTH University Clinic Aachen, Aachen, Germany, Pauwelsstraβe 30, 52074 Aachen

4. Marcel Bestch

   University of Toronto · Women's College Hospital

   Affiliation as printed

   University of Toronto Orthopaedic Sports Medicine Program (UTOSM), Women’s College Hospital, 76 Grenville St, Toronto, ON, Canada

   University of Toronto Orthopaedic Sports Medicine Program (UTOSM), Women's College Hospital, 76 Grenville St, Toronto, ON, Canada

5. Markus Tingart Aachen Department of Orthopaedics

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Orthopaedics, RWTH University Clinic Aachen, Aachen, Germany, Pauwelsstraβe 30, 52074 Aachen

6. Alice Baroncini Aachen Department of Orthopaedics

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Orthopaedics, El Hadara University Hospital Lambroso, Alexandria, Egypt

   Department of Orthopaedics, RWTH University Clinic Aachen, Aachen, Germany, Pauwelsstraβe 30, 52074 Aachen