Combining inhomogeneous magnetization transfer and multipoint Dixon acquisition: Potential utility and evaluation
Magnetic Resonance in Medicine, vol. 85, pp. 2136–2144
Abstract
PURPOSE: The recently introduced inhomogeneous magnetization transfer (ihMT) method has predominantly been applied for imaging the central nervous system. Future applications of ihMT, such as in peripheral nerves and muscles, will involve imaging in the vicinity of adipose tissues. This work aims to systematically investigate the partial volume effect of fat on the ihMT signal and to propose an efficient fat-separation method that does not interfere with ihMT measurements. METHODS: First, the influence of fat on ihMT signal was studied using simulations. Next, the ihMT sequence was combined with a multi-echo Dixon acquisition for fat separation. The sequence was tested in 9 healthy volunteers using a 3T human scanner. The ihMT ratio (ihMTR) values were calculated in regions of interest in the brain and the spinal cord using standard acquisition (no fat saturation), water-only, in-phase, and out-of-phase reconstructions. The values obtained were compared with a standard fat suppression method, spectral presaturation with inversion recovery. RESULTS: Simulations showed variations in the ihMTR values in the presence of fat, depending on the TEs used. The IhMTR values in the brain and spinal cord derived from the water-only ihMT multi-echo Dixon images were in good agreement with values from the unsuppressed sequence. The ihMT-spectral presaturation with inversion recovery combination resulted in 24%-35% lower ihMTR values compared with the standard non-fat-suppressed acquisition. CONCLUSION: The presence of fat within a voxel affects the ihMTR calculations. The IhMT multi-echo Dixon method does not compromise the observable ihMT effect and can potentially be used to remove fat influence in ihMT.
Authors 12
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Ece Ercan corresponding Aachen C.J. Gorter Center for High Field MRI Department of Radiology, Leiden University Medical Center
Leiden University Medical Center · The University of Texas Southwestern Medical Center
Affiliation as printed
C.J. Gorter Center for High Field MRI Department of Radiology Leiden University Medical Center Leiden the Netherlands
Department of Radiology UT Southwestern Medical Center Dallas TX USA
C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
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Beth Israel Deaconess Medical Center · Harvard University
Affiliation as printed
Division of MR Research Beth Israel Deaconess Medical Center Harvard Medical School Radiology, Boston MA USA
Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Radiology, Boston, MA, USA
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The University of Texas Southwestern Medical Center
Affiliation as printed
Advanced Imaging Research Center UT Southwestern Medical Center Dallas TX USA
Philips Healthcare Gainesville FL USA
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA
Philips Healthcare, Gainesville, FL, USA
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The University of Texas Southwestern Medical Center
Affiliation as printed
Department of Population and Data Sciences UT Southwestern Medical Center Dallas TX USA
Department of Radiology UT Southwestern Medical Center Dallas TX USA
Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
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The University of Texas Southwestern Medical Center
Affiliation as printed
Advanced Imaging Research Center UT Southwestern Medical Center Dallas TX USA
Department of Radiology UT Southwestern Medical Center Dallas TX USA
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
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The University of Texas Southwestern Medical Center
Affiliation as printed
Department of Radiology UT Southwestern Medical Center Dallas TX USA
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
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The University of Texas MD Anderson Cancer Center · The University of Texas Southwestern Medical Center
Affiliation as printed
Department of Cancer Systems Imaging UT MD Anderson Cancer Center Houston TX USA
Department of Radiology UT Southwestern Medical Center Dallas TX USA
Department of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX, USA
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
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The University of Texas Southwestern Medical Center
Affiliation as printed
Department of Radiology UT Southwestern Medical Center Dallas TX USA
Global MR Application and Workflow GE Healthcare Houston TX USA
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
Global MR Application and Workflow, GE Healthcare, Houston, TX, USA
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The University of Texas Southwestern Medical Center
Affiliation as printed
Advanced Imaging Research Center UT Southwestern Medical Center Dallas TX USA
Department of Radiology UT Southwestern Medical Center Dallas TX USA
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
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The University of Texas Southwestern Medical Center
Affiliation as printed
Advanced Imaging Research Center UT Southwestern Medical Center Dallas TX USA
Department of Radiology UT Southwestern Medical Center Dallas TX USA
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
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Beth Israel Deaconess Medical Center · Harvard University
Affiliation as printed
Division of MR Research Beth Israel Deaconess Medical Center Harvard Medical School Radiology, Boston MA USA
Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Radiology, Boston, MA, USA
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The University of Texas Southwestern Medical Center
Affiliation as printed
Advanced Imaging Research Center UT Southwestern Medical Center Dallas TX USA
Department of Radiology UT Southwestern Medical Center Dallas TX USA
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
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