Interaction between high-density lipoproteins and inflammation: Function matters more than concentration!

Advanced Drug Delivery Reviews, vol. 159, pp. 94–119

Abstract

High-density lipoprotein (HDL) plays an important role in lipid metabolism and especially contributes to the reverse cholesterol transport pathway. Over recent years it has become clear that the effect of HDL on immune-modulation is not only dependent on HDL concentration but also and perhaps even more so on HDL function. This review will provide a concise general introduction to HDL followed by an overview of post-translational modifications of HDL and a detailed overview of the role of HDL in inflammatory diseases. The clinical potential of HDL and its main apolipoprotein constituent, apoA-I, is also addressed in this context. Finally, some conclusions and remarks that are important for future HDL-based research and further development of HDL-focused therapies are discussed.

Authors 6

1. Sumra Nazir Aachen Institute for Molecular Cardiovascular Research (IMCAR) Interdisciplinary Center for Clinical Research (IZKF)

   RWTH Aachen University

   Affiliation as printed

   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany

   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

   Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany

2. Vera Jankowski Aachen Institute for Molecular Cardiovascular Research (IMCAR)

   RWTH Aachen University

   Affiliation as printed

   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

3. Guzide Bender Aachen Institute for Molecular Cardiovascular Research (IMCAR) Interdisciplinary Center for Clinical Research (IZKF)

   RWTH Aachen University

   Affiliation as printed

   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany

   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

   Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany

4. Stephen Zewinger

   Universitätsklinikum des Saarlandes · Hôpital Kirchberg · Saarland University

   Affiliation as printed

   Department of Internal Medicine 4, Nephrology and Hypertension, Saarland University Medical Centre, Homburg, Germany; Department of Nephrology, Hôpitaux Robert Schuman, Hôpital Kirchberg, Luxembourg, Luxembourg

   Department of Internal Medicine 4, Nephrology and Hypertension, Saarland University Medical Centre, Homburg, Germany

   Department of Nephrology, Hôpitaux Robert Schuman, Hôpital Kirchberg, Luxembourg, Luxembourg

5. Kerry‐Anne Rye

   UNSW Sydney

   Affiliation as printed

   Lipid Research Group, School of Medical Sciences, The University of New South Wales Sydney, New South Wales, Australia

6. Emiel P. C. van der Vorst corresponding Aachen Institute for Molecular Cardiovascular Research (IMCAR) Interdisciplinary Center for Clinical Research (IZKF)

   Maastricht University Medical Centre · German Centre for Cardiovascular Research · Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten · Ludwig-Maximilians-Universität München · RWTH Aachen University

   Affiliation as printed

   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, Netherlands; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany. Electronic address: evandervorst@ukaachen.de

   Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, Netherlands

   German Centre for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany

   Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Munich, Germany

   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

   Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany