Step and redox efficient nitroarene to indole synthesis

Chemical Communications, vol. 56, pp. 13185–13188

Abstract

Step and redox efficiencies are a rising priority in synthetic method development, in order to make synthetic processes more sustainable and more affordable. Herein, a step and redox efficient nitroarene to indole synthesis is developed, in sharp contrast to the rich literature on the construction of indoles. Elemental zinc was found to be the best terminal reductant.

Authors 3

1. Bünyamin Özkaya Aachen Institute of Organic Chemistry

   RWTH Aachen University

   Affiliation as printed

   52074 Aachen

   Germany

   Institute of Organic Chemistry

   RWTH Aachen University

   Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany

2. Christina L. Bub Aachen Institute of Organic Chemistry

   RWTH Aachen University

   Affiliation as printed

   52074 Aachen

   Germany

   Institute of Organic Chemistry

   RWTH Aachen University

   Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany

3. Frédéric W. Patureau corresponding Aachen Institute of Organic Chemistry

   RWTH Aachen University

   Affiliation as printed

   52074 Aachen

   Germany

   Institute of Organic Chemistry

   RWTH Aachen University

   Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany