Big data and reference intervals: rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data
Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, vol. 2, pp. 9–16
Abstract
Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on "big data" and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, including harmonization and standardization, and future perspectives of the indirect determination of reference intervals using routine laboratory data.
Authors 9
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Luisa María Martínez-Sánchez corresponding Aachen Department of Clinical Chemistry Laboratory Medicine
Leiden University · Universitat Autònoma de Barcelona · Leiden University Medical Center · Vall d'Hebron Hospital Universitari
Affiliation as printed
Clinical Biochemistry Department , Vall d’Hebron University Hospital , Barcelona , Spain
Department de Bioquímica i Biologia Molecular , Universitat Autònoma de Barcelona , Bellaterra , Spain
Department of Clinical Chemistry and Laboratory Medicine , Leiden University Medical Centre , Leiden , The Netherlands
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Universidad de Salamanca · Complejo Hospitalario de Salamanca
Affiliation as printed
Department of Clinical Biochemistry , University Hospital of Salamanca , Salamanca , Spain
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Affiliation as printed
Department of Medical Biochemistry , Uludag University School of Medicine , Bursa , Turkey
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Vall d'Hebron Hospital Universitari
Affiliation as printed
Clinical Biochemistry Department , Vall d’Hebron University Hospital , Barcelona , Spain
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Affiliation as printed
Diagnost-IQ, Expert Centre for Clinical Chemistry , Purmerend , The Netherlands
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Universitat Autònoma de Barcelona
Affiliation as printed
Laboratori de Referència d’Enzimologia Clínica, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona , Bellaterra , Spain
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Clinical Chemistry and Laboratory Medicine , Leiden University Medical Centre , Leiden , The Netherlands
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Affiliation as printed
Laboratory for Clinical Chemistry and Hematology, Amphia , Breda , The Netherlands
Stichting Kwaliteitsbewaking Medische Laboratoriumdiagnostiek , Nijmegen , The Netherlands
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Clinical Chemistry and Laboratory Medicine , Leiden University Medical Centre , Leiden , The Netherlands
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