Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

medRxiv

Abstract

Abstract Background Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favorable clinical outcome compared to other gliomas and a long-time survival that ranges between 10-20 years. However, during the course of the disease, multiple recurrences occur and the optimal treatment at each stage of the disease remains unclear. Here we report a retrospective longitudinal observation study of 836 MRI examinations in 44 ODG patients. Methods We quantified the volume of T2-hyperintensity to compute growth behavior in dependence of different treatment modalities, using various computational models. Results The identified growth pattern revealed dynamic changes, which were found to be patient-specific an did not correlate with clinical parameter or therapeutic interventions. Further, we showed that, surgical resection is beneficial for overall survival regardless the WHO grad or timepoint of surgery. To improve overall survival, an extent of resection above 50% is required. Multiple resections do not generally improve overall survival, except a greater extent of resection than in previous surgeries was achieved. Conclusions Our data aids to improve the interpretation of MRI images in clinical practice.

Authors 14

1. Dieter Henrik Heiland corresponding

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Neurosurgery, Medical Center, University of Freiburg, Germany

   Medical Faculty, Freiburg University, Germany

   Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Germany

2. Robin Ohle

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Neurosurgery, Medical Center, University of Freiburg, Germany

   Medical Faculty, Freiburg University, Germany

   Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Germany

3. Debora Cipriani

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Neurosurgery, Medical Center, University of Freiburg, Germany

   Medical Faculty, Freiburg University, Germany

   Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Germany

4. Pamela Franco

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Neurosurgery, Medical Center, University of Freiburg, Germany

   Medical Faculty, Freiburg University, Germany

   Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Germany

5. Daniel Delev Aachen Department of Neurosurgery, University of Aachen

   RWTH Aachen University

   Affiliation as printed

   Department of Neurosurgery, University of Aachen, Aachen, Germany

6. Simon P. Behriger

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Neurosurgery, Medical Center, University of Freiburg, Germany

   Medical Faculty, Freiburg University, Germany

   Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Germany

7. Elias Kellner

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Medical Physics, Department of Radiology, Medical Centre - University of Freiburg, Germany

8. Nicolas Noel Neidert

   University of Freiburg · University Medical Center Freiburg

   Affiliation as printed

   Department of Neurosurgery, Medical Center, University of Freiburg, Germany

   Medical Faculty, Freiburg University, Germany

   Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Germany

9. Irina Mader

   Schön Klinik Vogtareuth

   Affiliation as printed

   Clinic for Neuropediatrics and Neurorehabilitation, Epilepsy Center for Children and Adolescents, Schön Klinik, Vogtareuth, Germany

10. Mateo Fariña Nuñez

    University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    Department of Neurosurgery, Medical Center, University of Freiburg, Germany

    Medical Faculty, Freiburg University, Germany

    Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Germany

11. Horst Urbach

    University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    Department of Neuroradiology, Medical Center - University of Freiburg, Germany

    Medical Faculty, Freiburg University, Germany

12. Roman Sankowski

    University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    Berta-Ottenstein-Programme for Clinician Scientists Medical Center - University of Freiburg, Germany

    Institute of Neuropathology, Medical Center - University of Freiburg, Germany

    Medical Faculty, Freiburg University, Germany

13. Jürgen Beck

    University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    Department of Neurosurgery, Medical Center, University of Freiburg, Germany

    Medical Faculty, Freiburg University, Germany

14. Oliver Schnell

    University of Freiburg · University Medical Center Freiburg

    Affiliation as printed

    Department of Neurosurgery, Medical Center, University of Freiburg, Germany

    Medical Faculty, Freiburg University, Germany

    Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Germany