A framework for assessing neuropsychiatric phenotypes by using smartphone-based location data
Translational Psychiatry, vol. 10, pp. 211
Abstract
The use of smartphone-based location data to quantify behavior longitudinally and passively is rapidly gaining traction in neuropsychiatric research. However, a standardized and validated preprocessing framework for deriving behavioral phenotypes from smartphone-based location data is currently lacking. Here, we present a preprocessing framework consisting of methods that are validated in the context of geospatial data. This framework aims to generate context-enriched location data by identifying stationary, non-stationary, and recurrent stationary states in movement patterns. Subsequently, this context-enriched data is used to derive a series of behavioral phenotypes that are related to movement. By using smartphone-based location data collected from 245 subjects, including patients with schizophrenia, we show that the proposed framework is effective and accurate in generating context-enriched location data. This data was subsequently used to derive behavioral readouts that were sensitive in detecting behavioral nuances related to schizophrenia and aging, such as the time spent at home and the number of unique places visited. Overall, our results indicate that the proposed framework reliably preprocesses raw smartphone-based location data in such a manner that relevant behavioral phenotypes of interest can be derived.
Authors 13
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Affiliation as printed
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands
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Affiliation as printed
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands
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University Medical Center Groningen · University of Groningen · Erasmus MC
Affiliation as printed
Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands
Department of Neuroscience, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
Department of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam · Amsterdam UMC Location Vrije Universiteit Amsterdam
Affiliation as printed
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam · Amsterdam UMC Location Vrije Universiteit Amsterdam
Affiliation as printed
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
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Nic J.A. van der Wee Aachen Department of Psychiatry, Leiden University Medical Center Leiden Institute for Brain and Cognition
Leiden University Medical Center
Affiliation as printed
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands
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Affiliation as printed
Department of Social and Behavioural Sciences, Interdisciplinary Social Science, Youth Studies, Utrecht University, Utrecht, The Netherlands
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Universidad Complutense de Madrid · Hospital General Universitario Gregorio Marañón · Centro de Investigación Biomédica en Red de Salud Mental
Affiliation as printed
Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, CIBERSAM, IiSGM, Universidad Complutense, School of Medicine, Madrid, Spain
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University Medical Center Groningen · University of Groningen
Affiliation as printed
Department of Neuroscience, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Utrecht University · University Medical Center Utrecht
Affiliation as printed
Julius Center for Health Sciences and Primary Care, Department of Biostatistics and Research Support, University Medical Center Utrecht, Utrecht, The Netherlands
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University of Toronto · Hospital for Sick Children
Affiliation as printed
Department of Psychiatry, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
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Martien J. Kas corresponding
Affiliation as printed
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands. m.j.h.kas@rug.nl
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands
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