Age-associated changes in 4D flow CMR derived Tricuspid Valvular Flow and Right Ventricular Blood Flow Kinetic Energy
Scientific Reports, vol. 10, pp. 9908
Abstract
Abstract Assessment of right ventricular (RV) diastolic function is not routinely carried out. This is due to standard two-dimensional imaging techniques being unreliable. Four-dimensional flow (4D flow) derived right ventricular blood flow kinetic energy assessment could circumvent the issues of the current imaging modalities. It also remains unknown whether there is an association between right ventricular blood flow kinetic energy (KE) and healthy ageing. We hypothesise that healthy ageing requires maintaining normal RV intra-cavity blood flow as quantified using KE method. The main objective of this study was to investigate the effect of healthy ageing on tricuspid through-plane flow and right ventricular blood flow kinetic energy. In this study, fifty-three healthy participants received a 4D flow cardiovascular magnetic resonance (CMR) scan on 1.5 T Philips Ingenia. Cine segmentation and 4D flow analysis were performed using dedicated software. Standard statistical methods were carried out to investigate the associations. Both RV E-wave KEiEDV (r = −0.3, P = 0.04) and A-wave KEiEDV (r = 0.42, P < 0.01) showed an association with healthy ageing. Additionally, the right ventricular blood flow KEiEDV E/A ratio demonstrated the strongest association with healthy ageing (r = −0.53, P < 0.01) when compared to all RV functional and haemodynamic parameters. Furthermore, in a multivariate regression model, KEiEDV E/A ratio and 4D flow derived tricuspid valve stroke volume demonstrated independent association to healthy ageing (beta −0.02 and 0.68 respectively, P < 0.01). Ageing is independently associated with 4D flow derived tricuspid stroke volume and RV blood flow KE E/A ratio. These novel 4D flow CMR derived imaging markers have future potential for RV diastolic assessment.
Authors 12
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Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
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Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
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Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
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Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
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Sheffield Teaching Hospitals NHS Foundation Trust · University of Sheffield
Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
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Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
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Sheffield Teaching Hospitals NHS Foundation Trust · Insigneo · University of Sheffield
Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
Insigneo Institute for in-silico Medicine, Sheffield, UK
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
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Rob J. van der Geest Aachen Cardiovascular Imaging Group Department of Radiology, Leiden University Medical Center
Leiden University · Leiden University Medical Center
Affiliation as printed
Cardiovascular Imaging Group, Department of Radiology, Leiden University Medical Centre, Sheffield, UK
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Jos J.M. Westenberg Aachen Cardiovascular Imaging Group Department of Radiology, Leiden University Medical Center
Leiden University · Leiden University Medical Center
Affiliation as printed
Cardiovascular Imaging Group, Department of Radiology, Leiden University Medical Centre, Sheffield, UK
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Insigneo · University of Sheffield
Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
Insigneo Institute for in-silico Medicine, Sheffield, UK
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Affiliation as printed
Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
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Pankaj Garg corresponding
Affiliation as printed
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK. p.garg@sheffield.ac.uk
Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK
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