Randomized controlled trial of multi‐modular motion‐assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment‐resistant post‐traumatic stress disorder
Acta Psychiatrica Scandinavica, vol. 142, pp. 141–151
Abstract
OBJECTIVE: To explore the potential efficacy of multi-modular motion-assisted memory desensitization and reprocessing (3MDR) in British military veterans with treatment-resistant service-related PTSD. METHODS: Exploratory single-blind, randomized, parallel arm, cross-over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome. RESULTS: A total of 42 participants (all male) were randomized with 83% retention at 12 weeks and 86% at 26 weeks. The difference in mean Clinician-Administered PTSD Scale for DSM-5 scores between the immediate and delayed 3MDR arms was -9.38 (95% CI -17.33 to -1.44, P = 0.021) at 12 weeks and -3.59 (-14.39 to 7.20, P = 0.513) at 26 weeks when both groups had received 3MDR. The likely effect size of 3MDR was found to be 0.65. Improvements were maintained at 26-week follow-up. 3MDR was found to be acceptable to most, but not all, participants. Several factors that may impact efficacy and acceptability of 3MDR were identified. CONCLUSION: 3MDR is a promising new intervention for treatment-resistant PTSD with emerging evidence of effect.
Authors 11
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Jonathan I. Bisson corresponding
Affiliation as printed
School of Medicine Cardiff University Cardiff UK
Jonathan Bisson, School of Medicine, Cardiff University, Cardiff, UK
School of Medicine, Cardiff University, Cardiff, UK
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Affiliation as printed
School of Healthcare Sciences Cardiff University Cardiff UK
School of Healthcare Sciences, Cardiff University, Cardiff, UK
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Affiliation as printed
School of Healthcare Sciences Cardiff University Cardiff UK
School of Healthcare Sciences, Cardiff University, Cardiff, UK
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Cardiff and Vale University Health Board · National Health Service Wales
Affiliation as printed
Veterans' NHS Wales Cardiff and Vale University Health Board Cardiff UK
Veterans' NHS Wales, Cardiff and Vale University Health Board, Cardiff, UK
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Affiliation as printed
School of Medicine Cardiff University Cardiff UK
School of Medicine, Cardiff University, Cardiff, UK
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Affiliation as printed
Centre for Trials Research Cardiff University Cardiff UK
Centre for Trials Research, Cardiff University, Cardiff, UK
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Affiliation as printed
School of Medicine Cardiff University Cardiff UK
School of Medicine, Cardiff University, Cardiff, UK
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Affiliation as printed
School of Healthcare Sciences Cardiff University Cardiff UK
School of Healthcare Sciences, Cardiff University, Cardiff, UK
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Marieke J. van Gelderen Aachen Department of Psychiatry Leiden University Medical Center Leiden The Netherlands Department of Psychiatry, Leiden University Medical Center
Leiden University Medical Center
Affiliation as printed
Department of Psychiatry Leiden University Medical Center Leiden The Netherlands
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
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Arq Psychotrauma Expert Group · Amsterdam University Medical Centers
Affiliation as printed
ARQ Centrum'45 ARQ National Psychotrauma Centre Diemen The Netherlands
Department of Psychiatry Amsterdam University Medical Centres Amsterdam The Netherlands
ARQ Centrum'45, ARQ National Psychotrauma Centre, Diemen, The Netherlands
Department of Psychiatry, Amsterdam University Medical Centres, Amsterdam, The Netherlands
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Eric H. G. J. M. Vermetten Aachen Department of Psychiatry Leiden University Medical Center Leiden The Netherlands Department of Psychiatry, Leiden University Medical Center
Leiden University Medical Center
Affiliation as printed
Department of Psychiatry Leiden University Medical Center Leiden The Netherlands
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
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