Host–microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease

European Respiratory Journal, vol. 56, pp. 1902320

Abstract

Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, there is new and increasing evidence that communities of micro-organisms in our body, the human microbiome, are crucially involved in the development and progression of chronic respiratory diseases. Understanding the detailed mechanisms underlying this cross-talk between host and microbiota is critical for development of microbiome- or host-targeted therapeutics and prevention strategies. Here we review and discuss the most recent knowledge on the continuous reciprocal interaction between the host and microbes in health and respiratory disease. Furthermore, we highlight promising developments in microbiome-based therapies and discuss the need to employ more holistic approaches of restoring both the pulmonary niche and the microbial community.

Authors 10

1. Reinoud Gosens

   University of Groningen

   Affiliation as printed

   University of Groningen, Dept of Molecular Pharmacology, GRIAC Research Institute, Groningen, The Netherlands

2. Pieter Sicco Hiemstra Aachen Dept of Pulmonology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Dept of Pulmonology, Leiden University Medical Center (LUMC), Leiden, The Netherlands

3. Ian Michael Adcock

   Imperial College London

   Affiliation as printed

   Airways Disease, National Heart and Lung Institute, Imperial College London, London, UK

4. Ken R. Bracke

   Ghent University Hospital

   Affiliation as printed

   Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium

5. Robert P. Dickson

   University of Michigan · Michigan Medicine

   Affiliation as printed

   Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA

   Michigan Center for Integrative Research in Critical Care, Ann Arbor, MI, USA

6. Philip M. Hansbro

   University of Technology Sydney · Centenary Institute · Hunter Medical Research Institute · University of Newcastle Australia

   Affiliation as printed

   Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, Australia

   Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and the University of Newcastle, Newcastle, Australia

7. Susanne Krauss‐Etschmann

   Christian-Albrechts-Universität zu Kiel · Research Center Borstel - Leibniz Lung Center · German Center for Lung Research

   Affiliation as printed

   Early Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Airway Research Center North, Member of the German Center for Lung Research (DZL), Borstel, Germany

   Institute for Experimental Medicine, Christian-Albrechts-Universitaet zu Kiel, Kiel, Germany

8. Hermelijn H. Smits Aachen Department of Parasitology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Dept of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

9. Frank R. M. Stassen

   Maastricht University Medical Centre · Maastricht University

   Affiliation as printed

   Dept of Medical Microbiology, NUTRIM - School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands

   Dept of Medical Microbiology, NUTRIM – School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands

10. Sabine Bartel

    University Medical Center Groningen · University of Groningen · Research Center Borstel - Leibniz Lung Center · German Center for Lung Research

    Affiliation as printed

    Early Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Airway Research Center North, Member of the German Center for Lung Research (DZL), Borstel, Germany s.r.bartel@umcg.nl

    University of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, GRIAC Research Institute, Groningen, The Netherlands

    Early Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Airway Research Center North, Member of the German Center for Lung Research (DZL), Borstel, Germany