Headache Perception in an Epilepsy Patient with Neuromodulation by Anterior Thalamic Nuclei Deep Brain Stimulation: A Case Report

Journal of Neurological Surgery Part A Central European Neurosurgery, vol. 81, pp. 368–371

Abstract

OBJECTIVE: Headache disorders are frequently associated with epilepsy. Some neuromodulation techniques for refractory epilepsy have been reported to positively influence the associated chronic headache. However, the exact mechanism of action of vagus nerve stimulation (VNS) and anterior thalamic nuclei-deep brain stimulation (ANT-DBS) on pain perception is unclear. METHOD: We report a structured assessment of pain perception in a patient who experienced headache relief after ANT-DBS for refractory focal epilepsy and compare it with pain perception of epilepsy patients with chronic headache who were treated with and without VNS. RESULTS: The pain-associated symptoms in the ANT-DBS case were on the Pain Anxiety Symptoms Scale (PASS-40) subscore "physiological anxiety" closer to the control collective, whereas in patients with VNS, this was more likely for the PASS-40 subscores "cognitive anxiety" or "escape and avoidance." CONCLUSION: ANT-DBS and VNS may influence epilepsy-associated chronic headache in different ways.

Authors 3

1. Bogdan Pintea corresponding

   University Hospital Bonn · BG University Hospital Bergmannsheil Bochum

   Affiliation as printed

   Department of Neurosurgery, Universitatsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany

   Neurochriurgie, Berufsgenossenschaftliches Universitatsklinikum Bergmannsheil, Bochum, Germany

2. Rainer Surges Aachen Department of Neurology Section of Epileptology

   RWTH Aachen University · Universitätsklinikum Aachen · University Hospital Bonn

   Affiliation as printed

   Department of Epileptology, Universitatsklinikum Bonn Zentrum fur Nervenheilkunde, Bonn, Nordrhein-Westfalen, Germany

   Section of Epileptology, Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany

3. Jan Patrick Boström

   University Hospital Bonn

   Affiliation as printed

   Department of Neurosurgery, Universitatsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany