Author response to: Comment on: External validation of a prognostic model to predict survival of patients with sentinel node-negative melanoma
British journal of surgery, vol. 107, pp. 616
Abstract
Editor The authors initially developed and published the European Organisation for Research and Treatment of Cancer (EORTC) calculator for predicting risk of recurrence and melanoma-specific mortality for sentinel node-negative melanoma patients1. This calculator is now validated through a geographical external study that ensures the transportability of the predictive performance of the model to the Australian population2. The AJCC has recognized the importance of accurate individualized prediction models3. The EORTC prognostic model is useful to clinicians, researchers and melanoma patients. Its online availability enables worldwide accurate identification of high-risk melanoma patients. This will further personalize management including decisions on adjuvant therapy, selection of patients for counselling and the creation of suitable follow-up regimens. However, we hope the prognostic model will be externally validated in more populations to ensure wider generalizability of the nomogram. To improve the predictive performance of the model, new biomarkers should be explored in the future.
Authors 3
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Leiden University · Leiden University Medical Center · Melanoma Institute Australia
Affiliation as printed
Department of Dermatology, Leiden University Medical Centre , Leiden, The Netherlands
Melanoma Institute Australia , Sydney, New South Wales, Australia
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The University of Sydney · Royal Prince Alfred Hospital · Melanoma Institute Australia
Affiliation as printed
Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital , Sydney, New South Wales, Australia
Melanoma Institute Australia , Sydney, New South Wales, Australia
Sydney Medical School, University of Sydney , Sydney, New South Wales, Australia
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Affiliation as printed
Melanoma Institute Australia , Sydney, New South Wales, Australia
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