Evaluation of Left Ventricular Assist Device Electrical Current as a Predictor of Left Ventricular Recovery

Preprints.org

Abstract

In this paper, we aim to assess the electric current parameters and report the analysis of the associated degree of ventricular recovery during left ventricular assist device (LVAD) support. An assumption was made there is a linear relationship between ventricular recovery degree and the pump electric current pulsatility index (PI). The experimental study was carried out using the ViVitro Pulse Duplicator System with Sputnik 1 LVAD connected. Cardiac output (CO) and cardiac power output (CPO) were used as a measure of ventricular recovery degree. Different heart rates (HR) (59, 73, 86 bpm) and pump speeds (7600–8400 rpm in 200 rpm steps) were investigated. Ventricular stroke volumes in the range of 30–80 ml for each heart rate at certain pump speed were used. The obtained relationships of CO and CPO vs. PI was linear as the coefficients of determination for each regression curve were more than 0.8. CO vs. PI: R2=0.9218; 0.9271; 0.9172 and CPO vs. PI: R2=0.8517; 0.841; 0.8244 for HR=59 bpm; 73 bpm; 86 bpm, respectively. Study findings suggest that adequate interpretation of parameters could potentially serve as a valuable clinical tool to assess ventricular recovery based on LVAD infrastructure without requiring any special hemodynamic assessment.

Authors 8

1. Dmitry V. Telyshev corresponding

   Sechenov University · National Research University of Electronic Technology

   Affiliation as printed

   Institute for Bionic Technologies and Engineering , I. M. Sechenov First Moscow State Medical University , 119991 , Moscow , Russian Federation

   Institute of Biomedical Systems , National Research University of Electronic Technology , Zelenograd , 124498 , Moscow , Russian Federation

   Institute for Bionic Technologies and Engineering, I. M. Sechenov First Moscow State Medical University, 119991, Moscow, Russian Federation

   Institute of Biomedical Systems, National Research University of Electronic Technology, Zelenograd, 124498, Moscow, Russian Federation

2. Alexander A. Pugovkin

   National Research University of Electronic Technology

   Affiliation as printed

   Institute of Biomedical Systems , National Research University of Electronic Technology , Zelenograd , 124498 , Moscow , Russian Federation

   Institute of Biomedical Systems, National Research University of Electronic Technology, Zelenograd, 124498, Moscow, Russian Federation

3. Ivan A. Ephimov

   National Research University of Electronic Technology

   Affiliation as printed

   Institute of Biomedical Systems , National Research University of Electronic Technology , Zelenograd , 124498 , Moscow , Russian Federation

   Institute of Biomedical Systems, National Research University of Electronic Technology, Zelenograd, 124498, Moscow, Russian Federation

4. Aleksandr G. Markov

   Sechenov University

   Affiliation as printed

   Institute for Bionic Technologies and Engineering , I. M. Sechenov First Moscow State Medical University , 119991 , Moscow , Russian Federation

   Institute for Bionic Technologies and Engineering, I. M. Sechenov First Moscow State Medical University, 119991, Moscow, Russian Federation

5. Steffen K. Leonhardt Aachen

   RWTH Aachen University

   Affiliation as printed

   Helmholtz Institute of Biomedical Engineering , RWTH Aachen University , 52074 Aachen , Germany

   Helmholtz Institute of Biomedical Engineering, RWTH Aachen University, 52074 Aachen, Germany

6. Marian Walter Aachen

   RWTH Aachen University

   Affiliation as printed

   Helmholtz Institute of Biomedical Engineering , RWTH Aachen University , 52074 Aachen , Germany

   Helmholtz Institute of Biomedical Engineering, RWTH Aachen University, 52074 Aachen, Germany

7. Jamshid H. Karimov

   Cleveland Clinic

   Affiliation as printed

   Department of Biomedical Engineering , Lerner Research Institute , Cleveland Clinic , Cleveland , Ohio , OH 44195 USA

   Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, OH 44195 USA

8. Sergey V. Selishchev

   National Research University of Electronic Technology

   Affiliation as printed

   Institute of Biomedical Systems , National Research University of Electronic Technology , Zelenograd , 124498 , Moscow , Russian Federation

   Institute of Biomedical Systems, National Research University of Electronic Technology, Zelenograd, 124498, Moscow, Russian Federation