Common and separable neural alterations in substance use disorders: evidence from coordinate-based meta-analyses of functional neuroimaging studies in human
bioRxiv (Cold Spring Harbor Laboratory)
Abstract
Abstract Delineating common and separable neural alterations in substance use disorders (SUD) is imperative to understand the neurobiological basis of the addictive process and to inform substance-specific treatment strategies. Given numerous functional MRI (fMRI) studies in different SUDs, meta-analysis could provide an opportunity to determine robust shared and substance-specific alterations. The present study employed a coordinate-based meta-analysis covering fMRI studies in individuals with addictive cocaine, cannabis, alcohol, and nicotine use. The primary meta-analysis demonstrated common alterations in primary dorsal striatal, and frontal circuits engaged in reward/salience processing, habit formation, and executive control across different substances and task-paradigms. Subsequent sub-analyses revealed substance-specific alterations in frontal and limbic regions, with marked frontal and insula-thalamic alterations in alcohol and nicotine use disorders respectively. Finally, examining task-specific alterations across substances revealed pronounced frontal alterations during cognitive processes yet stronger striatal alterations during reward-related processes. Together the findings emphasize the role of dysregulations in striato-frontal circuits and dissociable contributions of these systems in the domains of reward-related and cognitive processes which may contribute to substance-specific behavioral alterations.
Authors 6
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University of Electronic Science and Technology of China
Affiliation as printed
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China
The Clinicl Hospitl of Chengdu Brin Science Institute, MOE Key Lbortory for Neuroinformtion, Center for Informtion in Medicine, School of Life Science nd Technology, University of Electronic Science nd Technology of Chin, No.2006, Xiyun Avenue, West Hi-Tech Zone, Chengdu, Sichun 611731, Chin
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New Jersey Institute of Technology
Affiliation as printed
Department of Biomedical Engineering, New Jersey Institute of Technology
Department of Biomedical Engineering, New Jersey Institute of Technology, 619 Fenster Hall, Newark, NJ 07102, USA
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Jana Zweerings Aachen Department of Psyhiatry, Psyhotherapy and Psyhosomatis JARA Translational Brain Meicine
Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine
JARA Translational Brain Medicine
Department of Psyhiatry, Psyhotherapy and Psyhosomatis, Faulty of Mediine, RWTH Aahen, Pauwelstrasse 30, 52074, Aahen, Germany
JARA Translational Brain Meicine, RWTH Aachen, Pauwelstrasse 30, 52074, Aachen, Germany
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Klaus Mathiak Aachen Department of Psyhiatry, Psyhotherapy and Psyhosomatis JARA Translational Brain Meicine
Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine
JARA Translational Brain Medicine
Department of Psyhiatry, Psyhotherapy and Psyhosomatis, Faulty of Mediine, RWTH Aahen, Pauwelstrasse 30, 52074, Aahen, Germany
JARA Translational Brain Meicine, RWTH Aachen, Pauwelstrasse 30, 52074, Aachen, Germany
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Benjamin Becker corresponding
University of Electronic Science and Technology of China
Affiliation as printed
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China
The Clinicl Hospitl of Chengdu Brin Science Institute, MOE Key Lbortory for Neuroinformtion, Center for Informtion in Medicine, School of Life Science nd Technology, University of Electronic Science nd Technology of Chin, No.2006, Xiyun Avenue, West Hi-Tech Zone, Chengdu, Sichun 611731, Chin
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Bharat B. Biswal corresponding
New Jersey Institute of Technology · University of Electronic Science and Technology of China
Affiliation as printed
Department of Biomedical Engineering, New Jersey Institute of Technology
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China
Department of Biomedical Engineering, New Jersey Institute of Technology, 619 Fenster Hall, Newark, NJ 07102, USA
The Clinicl Hospitl of Chengdu Brin Science Institute, MOE Key Lbortory for Neuroinformtion, Center for Informtion in Medicine, School of Life Science nd Technology, University of Electronic Science nd Technology of Chin, No.2006, Xiyun Avenue, West Hi-Tech Zone, Chengdu, Sichun 611731, Chin
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