Charting cellular identity during human in vitro β-cell differentiation

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  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Pancreatic function and diabetes Open access

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• Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitors

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• Deletion of RFX6, a Diabetes-Associated Gene, Impairs iPSC-Derived Islet Organoid Development and Survival, With No Impact on the Generation of PDX1+/NKX6.1+ Progenitors

  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Pancreatic function and diabetes Open access

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• Human pluripotent stem cell fate trajectories toward lung and hepatocyte progenitors

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• Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells

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• Type 1 diabetes and engineering enhanced islet transplantation

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• Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells

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• Single cell trajectory analysis of human pluripotent stem cells differentiating towards lung and hepatocyte progenitors

  2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access

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14 results