Machine-learning-guided directed evolution for protein engineering

• Global Dynamic Design (GDD) Empowers Cytochrome P450s for Improved Catalytic Performance

  2025 ACS Sustainable Chemistry & Engineering article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization

  2

  citations
• Evolutionary Probability and Stacked Regressions Enable Data-Driven Protein Engineering with Minimized Experimental Effort

  2024 Journal of Chemical Information and Modeling article Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics

  3

  citations
• Automated in vivo enzyme engineering accelerates biocatalyst optimization

  2024 Nature Communications article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access

  87

  citations
• TransMEP: Transfer learning on large protein language models to predict mutation effects of proteins from a small known dataset

  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Machine Learning in Bioinformatics Open access

  7

  citations
• Material-specific binding peptides empower sustainable innovations in plant health, biocatalysis, medicine and microplastic quantification

  2024 Chemical Society Reviews review Biochemistry, Genetics and Molecular Biology Biochemical and Structural Characterization Open access

  49

  citations
• Machine Learning-Assisted Engineering of Light, Oxygen, Voltage Photoreceptor Adduct Lifetime

  2023 JACS Au article Neuroscience Photoreceptor and optogenetics research Open access

  6

  citations
• Deep learning guided enzyme engineering of Thermobifida fusca cutinase for increased PET depolymerization

  2023 CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization

  37

  citations
• A hybrid model combining evolutionary probability and machine learning leverages data-driven protein engineering

  2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics Open access

  11

  citations
• Rational evolution of a recombinant DNA polymerase for efficient incorporation of unnatural nucleotides by dual-site boosting

  2022 Research Square preprint Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access

  0

  citations
• Evolution of E. coli Phytase Toward Improved Hydrolysis of Inositol Tetraphosphate

  2022 Frontiers in Chemical Engineering article Agricultural and Biological Sciences Phytase and its Applications Open access

  8

  citations
• Rational evolution of a recombinant DNA polymerase for efficient incorporation of unnatural nucleotides by dual-site boosting

  2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access

  0

  citations
• PyPEF—An Integrated Framework for Data-Driven Protein Engineering

  2021 Journal of Chemical Information and Modeling article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization

  39

  citations
• Machine learning-assisted enzyme engineering

  2020 Methods in enzymology on CD-ROM/Methods in enzymology book-chapter Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization

  122

  citations

13 results