Ubiquitin Ligases: Structure, Function, and Regulation

• Proteome-wide ubiquitinome profiling reveals substrate-specific dynamics within the USP7 network

  2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  0

  citations
• A modular Uba1-nanobody fusion enables selective ubiquitin transfer to tagged E2 enzymes

  2025 Journal of Biological Chemistry article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  1

  citations
• USP32 facilitates tumor development and is correlated with poor clinical outcomes in hepatocellular carcinoma patients and is modulated by the E2F7/miR-218-5p axis

  2025 LabMed discovery. article Biochemistry, Genetics and Molecular Biology MicroRNA in disease regulation Open access

  3

  citations
• TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains

  2025 Nature Structural & Molecular Biology article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  16

  citations
• Site-directed multivalent conjugation of antibodies to ubiquitinated payloads

  2025 Nature Biomedical Engineering article Medicine Monoclonal and Polyclonal Antibodies Research Open access

  6

  citations
• Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5

  2023 Nature Chemical Biology article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  81

  citations
• Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5

  2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  11

  citations
• Ubiquitin and its relatives as wizards of the endolysosomal system

  2023 Journal of Cell Science article Biochemistry, Genetics and Molecular Biology Cellular transport and secretion Open access

  15

  citations
• Ubi-tagging: A ubiquitin-based modular platform for site-directed antibody conjugation

  2022 Research Square preprint Medicine Monoclonal and Polyclonal Antibodies Research Open access

  5

  citations
• Transcriptome, metabolome and suppressor analysis reveal an essential role for the ubiquitin-proteasome system in seedling chloroplast development

  2022 BMC Plant Biology article Biochemistry, Genetics and Molecular Biology Photosynthetic Processes and Mechanisms Open access

  3

  citations
• Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class

  2021 ChemBioChem article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  46

  citations
• Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex

  2021 Cell Reports article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  77

  citations
• The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

  2021 Cell Reports article Biochemistry, Genetics and Molecular Biology Cellular transport and secretion Open access

  48

  citations
• Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler

  2020 Nature Chemical Biology article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  38

  citations
• ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatiotemporal control of the endolysosomal pathway

  2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Cellular transport and secretion Open access

  2

  citations
• Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code

  2020 Frontiers in Chemistry article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  58

  citations

16 results