Epistasis in protein evolution

• Phosphate ions modulate enzyme activity and epistatic effects in two clavulanic acid‐resistant β‐lactamase mutants

  2025 Protein Science article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  3

  citations
• KnowVolution of an Efficient Polyamidase through Molecular Dynamics Simulations of Incrementally Docked Oligomeric Substrates

  2025 ChemSusChem article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access

  8

  citations
• KnowVolution of an efficient polyamidase through molecular dynamics simulations of incrementally docked oligomeric substrates

  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access

  1

  citations
• Positive epistasis drives clavulanic acid resistance in double mutant libraries of BlaC β-lactamase

  2024 Communications Biology article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  7

  citations
• A hybrid model combining evolutionary probability and machine learning leverages data-driven protein engineering

  2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics Open access

  11

  citations

5 results