Macrodomains: Structure, Function, Evolution, and Catalytic Activities

• Dimerization of human PARP15 is required for NAD + binding and automodification

  2026 FEBS Journal article Medicine PARP inhibition in cancer therapy Open access

  0

  citations
• Screening assay to monitor mono-ADP-ribosylhydrolase activity of viral macrodomains in cells

  2026 Communications Biology article Immunology and Microbiology interferon and immune responses Open access

  1

  citations
• Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling

  2025 The EMBO Journal article Medicine Prostate Cancer Treatment and Research Open access

  10

  citations
• Family-wide analysis of human macrodomains reveals novel activities and identifies PARG as most efficient ADPr-RNA hydrolase

  2025 Communications Biology article Medicine PARP inhibition in cancer therapy Open access

  9

  citations
• Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling

  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Prostate Cancer Treatment and Research Open access

  0

  citations
• Evolutionary and molecular basis of ADP-ribosylation reversal by zinc-dependent macrodomains

  2024 Journal of Biological Chemistry article Biochemistry, Genetics and Molecular Biology Biochemical and Molecular Research Open access

  8

  citations
• Family-wide analysis of human macrodomains reveals novel activities

  2024 Research Square preprint Medicine PARP inhibition in cancer therapy Open access

  0

  citations
• Pathological and physiological roles of ADP-ribosylation: established functions and new insights

  2024 Biological Chemistry article Medicine PARP inhibition in cancer therapy

  3

  citations
• Mono‐ADP‐Ribosylation of Peptides: An Overview of Synthetic and Chemoenzymatic Methodologies

  2024 ChemBioChem article Biochemistry, Genetics and Molecular Biology Chemical Synthesis and Analysis Open access

  6

  citations
• Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

  2024 Nature Communications article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  16

  citations
• IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?

  2023 Pathogens article Immunology and Microbiology interferon and immune responses Open access

  9

  citations
• Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication

  2023 Cellular and Molecular Life Sciences article Medicine Mosquito-borne diseases and control Open access

  39

  citations
• Intracellular mono-ADP-ribosyltransferases at the host–virus interphase

  2022 Cellular and Molecular Life Sciences article Immunology and Microbiology interferon and immune responses Open access

  31

  citations
• ADP‐ribosyltransferases, an update on function and nomenclature

  2021 FEBS Journal article Biochemistry, Genetics and Molecular Biology Biochemical and Molecular Research Open access cited by 4 patents

  337

  citations
• Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

  2021 Nature Communications article Medicine PARP inhibition in cancer therapy Open access

  60

  citations
• The search for inhibitors of macrodomains for targeting the readers and erasers of mono-ADP-ribosylation

  2021 Drug Discovery Today article Medicine PARP inhibition in cancer therapy

  21

  citations
• ADP-ribosylation of RNA and DNA: from in vitro characterization to in vivo function

  2021 Nucleic Acids Research article Medicine PARP inhibition in cancer therapy Open access

  85

  citations
• Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

  2020 Nature Communications article Biochemistry, Genetics and Molecular Biology Biochemical and Structural Characterization Open access cited by 2 patents

  90

  citations
• The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis

  2020 Cancers article Medicine PARP inhibition in cancer therapy Open access

  31

  citations
• Mono-ADP-ribosylation by ARTD10 restricts Chikungunya virus replication by interfering with the proteolytic activity of nsP2

  2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology interferon and immune responses Open access

  10

  citations

20 results