Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

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• Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis

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• Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

  2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Telomeres, Telomerase, and Senescence Open access

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• Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging

  2022 Theranostics article Medicine Cardiac electrophysiology and arrhythmias Open access

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• Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes

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• Disease‐specific phenotypes in iPSC‐derived neural stem cells with POLG mutations

  2020 EMBO Molecular Medicine article Biochemistry, Genetics and Molecular Biology Mitochondrial Function and Pathology Open access

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• Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration

  2020 Frontiers in Immunology article Medicine Acute Kidney Injury Research Open access

  106

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8 results