April 08, 2011 article Open access A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis Science DOI: 10.1126/science.1198542 Full text (OA) OpenAlex Authors 0 Author list not loaded yet. Cited by 2 stored of 475 Search Sort Most cited Newest Oldest Patent citations Title Any typearticle review book-chapter conference-paper preprint dissertation book dataset other Any fieldAgricultural and Biological Sciences Arts and Humanities Biochemistry, Genetics and Molecular Biology Business, Management and Accounting Chemical Engineering Chemistry Computer Science Decision Sciences Dentistry Earth and Planetary Sciences Economics, Econometrics and Finance Energy Engineering Environmental Science Health Professions Immunology and Microbiology Materials Science Mathematics Medicine Neuroscience Nursing Pharmacology, Toxicology and Pharmaceutics Physics and Astronomy Psychology Social Sciences Veterinary Open access Hook loop dynamics engineering transcended the barrier of activity-stability trade-off and boosted the thermostability of enzymes 2024 International Journal of Biological Macromolecules article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization 21 citations A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the β-lactamase BlaC 2024 International Journal of Biological Macromolecules article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access 7 citations 2 results References 0