A new antibiotic kills pathogens without detectable resistance

• Bacterial cell envelope-targeting antibiotics

  2025 Nature Reviews Microbiology review Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  28

  citations
• Trans-kingdom conservation of mechanism between bacterial actifensin and eukaryotic defensins

  2025 npj Antimicrobials and Resistance article Immunology and Microbiology Antimicrobial Peptides and Activities Open access

  4

  citations
• Combination of bacteriophage and antibiotic therapy to control antimicrobial drug resistance bacterial infections: the evolutionary trade-off mechanism

  2024 Reviews in Medical Microbiology article Environmental Science Bacteriophages and microbial interactions

  0

  citations
• Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity

  2024 Science Translational Medicine article Medicine Antimicrobial Resistance in Staphylococcus Open access

  26

  citations
• A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens

  2024 Proceedings of the National Academy of Sciences article Immunology and Microbiology Antimicrobial Peptides and Activities Open access

  28

  citations
• Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria

  2024 Nature Chemistry article Biochemistry, Genetics and Molecular Biology Cancer therapeutics and mechanisms Open access

  29

  citations
• Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial Activity

  2023 Journal of Medicinal Chemistry article Immunology and Microbiology Antimicrobial Peptides and Activities Open access

  19

  citations
• Targeting membrane-bound bacterial cell wall precursors: a tried and true antibiotic strategy in nature and the clinic

  2023 Chemical Communications article Medicine Microbial Natural Products and Biosynthesis

  23

  citations
• Metabolite discovery: Biochemistry’s scientific driver

  2022 Cell Metabolism article Biochemistry, Genetics and Molecular Biology Metabolomics and Mass Spectrometry Studies Open access cited by 1 patent

  97

  citations
• Berkchaetoazaphilone B has antimicrobial activity and affects energy metabolism

  2021 Scientific Reports article Medicine Microbial Natural Products and Biosynthesis Open access

  5

  citations
• Natural products in drug discovery: advances and opportunities

  2021 Nature Reviews Drug Discovery review Medicine Microbial Natural Products and Biosynthesis Open access cited by 8 patents

  5,478

  citations
• Ecology and genomics of Actinobacteria: new concepts for natural product discovery

  2020 Nature Reviews Microbiology review Medicine Microbial Natural Products and Biosynthesis Open access cited by 1 patent

  478

  citations

12 results