Principles of bioactive lipid signalling: lessons from sphingolipids

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  2

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• Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

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• The plasma lipidome varies with the severity of metabolic dysfunction-associated steatotic liver disease

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• Lipid Disbalance Affects Neuronal Dendrite Growth and Maintenance in a Human Ceramide Synthase Disease Model

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• The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures

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• Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model

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• Scavenger Receptor BI Deficiency in Mice Is Associated With Plasma Ceramide and Sphingomyelin Accumulation and a Reduced Cholesteryl Ester Fatty Acid Length and Unsaturation Degree

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• 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function

  2023 Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease article Medicine Chronic Kidney Disease and Diabetes Open access

  19

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• Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children

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• Characterization of the Sphingolipidome of the Peri-Infarct Tissue during Hemorrhagic Transformation in a Mouse Model of Cerebral Ischemia

  2022 Journal of Integrative Neuroscience article Biochemistry, Genetics and Molecular Biology Sphingolipid Metabolism and Signaling Open access

  3

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• Epidermal 1‐ O‐acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes

  2022 Lipids article Biochemistry, Genetics and Molecular Biology Sphingolipid Metabolism and Signaling Open access cited by 1 patent

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• Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N -acyl homoserine lactones

  2021 Proceedings of the National Academy of Sciences article Biochemistry, Genetics and Molecular Biology Cell death mechanisms and regulation Open access cited by 1 patent

  26

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• Arrangement of Ceramides in the Skin: Sphingosine Chains Localize at a Single Position in Stratum Corneum Lipid Matrix Models

  2020 Langmuir article Biochemistry, Genetics and Molecular Biology Lipid Membrane Structure and Behavior Open access

  27

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• Lyso-glycosphingolipids: presence and consequences

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• Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

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• Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting

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16 results