A standard numbering scheme for the class A β -lactamases

• Conserved Asp233–Asp246 hydrogen bond modulates active site dynamics in class A β ‐lactamases

  2026 Protein Science article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  0

  citations
• Phosphate ions modulate enzyme activity and epistatic effects in two clavulanic acid‐resistant β‐lactamase mutants

  2025 Protein Science article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  3

  citations
• Directed evolution of a beta‐lactamase samples a wide variety of conformational states

  2025 Protein Science article Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics Open access

  0

  citations
• A glycine at position 105 leads to clavulanic acid and avibactam resistance in class A β-lactamases

  2025 Journal of Biological Chemistry article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  2

  citations
• Klebsiella pneumoniae: A growing threat in the era of antimicrobial resistance

  2025 The Microbe article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  100

  citations
• A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the β-lactamase BlaC

  2024 International Journal of Biological Macromolecules article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  7

  citations
• Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC

  2024 Protein Science article Materials Science Enzyme Structure and Function Open access

  5

  citations
• Positive epistasis drives clavulanic acid resistance in double mutant libraries of BlaC β-lactamase

  2024 Communications Biology article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  7

  citations
• Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis

  2023 Scientific Reports article Medicine Tuberculosis Research and Epidemiology Open access

  7

  citations
• Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase

  2023 International Journal of Biological Macromolecules article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  13

  citations
• Asp179 in the class A β‐lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis

  2023 FEBS Journal article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  9

  citations
• The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam

  2021 Biochemistry article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  21

  citations
• Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics

  2021 Antimicrobial Agents and Chemotherapy article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  14

  citations
• Conserved residues Glu37 and Trp229 play an essential role in protein folding of β‐lactamase

  2021 FEBS Journal article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  9

  citations
• Plasmid diversity among genetically related Klebsiella pneumoniae blaKPC-2 and blaKPC-3 isolates collected in the Dutch national surveillance

  2020 Scientific Reports article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  44

  citations

15 results