SHELL MODIFICATION OF MICROBUBBLES
Abstract
The present invention relates, inter alia, to a method for producing a microbubble, comprising (i) providing a polymerizable monomer and a non-polymerizable compound; and (ii) polymerizing the monomer in an aqueous solvent in the presence of the non-polymerizable compound to form a polymeric shell encapsulating an inner lumen; wherein the polymerizable monomer is selected from the group consisting of alkyl cyanoacrylates, alkyl acrylates, lactide, glycolide, and combinations thereof; and the non-polymerizable compound is capable of integrating into the polymeric shell as the polymerization proceeds so as to form a plurality of non-polymerized nanocavities.
Inventors 5
- Roger M. Pallares Aachen author as filed: Molto Pallares, Roger
- Mirjavad Moosavifar Aachen author as filed: Moosavifar, Mirjavad
- Fabian M. Kiessling Aachen author as filed: Kiessling, Fabian
- Twan Lammers Aachen author as filed: Lammers, Twan
- Molto, Pallares Roger
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE AACHEN, ABGEKÜRZT RWTH AACHEN, KÖRPERSCHAFT DES ÖFFENTLICHEN RECHTS RWTH Aachen University
Cited papers 2 in the database
Non-patent literature as cited (2)
- - KOCZERA PATRICK ET AL: "PBCA-based polymeric microbubbles for molecular imaging and drug delivery", JOURNAL OF CONTROLLED RELEASE, vol. 259, 10 August 2017 (2017-08-10), NL, pages 128 - 135, XP093288306, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.03.006
- - MOOSAVIFAR MIRJAVAD ET AL: "Polymeric Microbubble Shell Engineering: Microporosity as a Key Factor to Enhance Ultrasound Imaging and Drug Delivery Performance", ADVANCED SCIENCE, vol. 11, no. 40, 29 August 2024 (2024-08-29), Germany, XP093323668, ISSN: 2198-3844, DOI: 10.1002/advs.202404385