UBIQUITIN VACCINE COMPONENTS
Abstract
Provided herein is a vaccine component comprising a ubiquitin covalently bonded to an antigen, wherein the vaccine component does not comprise a cell permeability tag; as well as vaccines comprising such a vaccine component. The vaccine component may be useful in the activation of dendritic cells. Also provided are combinations comprising such a vaccine component or vaccine and a biologically active substance; and formulations comprising such a vaccine component, vaccine, or combination. The vaccine component, vaccine, combination, or formulation may be used as a medicament, for example in the treatment of a condition selected from a cancer and an autoimmune disease.
Inventors 7
- Martijn Verdoes Aachen author as filed: Verdoes, Martijn
- Ferenc A. Scheeren Aachen author as filed: Scheeren, Ferenc A.
- Wijfjes, Zacharias
- El Hebieshy, Angela F.
- El Oualid, Farid
- El, Hebieshy Angela F
- El, Oualid Farid
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden
- UBIQ BIO BV
Cited papers 0 in the database
Non-patent literature as cited (1)
- - OLIVEIRA LILIANE M DE ET AL: "Expression, Polyubiquitination, and Therapeutic Potential of Recombinant E6E7 from HPV16 Antigens Fused to Ubiquitin", MOLECULAR BIOTECHNOLOGY, SPRINGER US, NEW YORK, vol. 59, no. 1, 26 December 2016 (2016-12-26), pages 46 - 56, XP036144571, ISSN: 1073-6085, [retrieved on 20161226], DOI: 10.1007/S12033-016-9990-6