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First published May 15, 2026 Application Aachen patent G – Physics

BARCODE FREE LIBRARY SCREEN

Espacenet Family 93923366

Abstract

The present invention relates to a method for identifying which members of a barcode-free library of small molecules bind to a target and elucidating their molecular structure, the method comprising: a) mixing the members of at least one subset of the library with the target; b) separating the members that do not bind to the target (nonbinders) from the members that bind to the target (binders); c) analysing the binders using tandem mass spectrometry (MS/MS) to generate MS/MS spectra of the binders; and d) analysing the MS/MS spectra by computational analysis to elucidate the molecular structure of the binders.

Inventors 5

  1. Sebastian J. Pomplun Aachen author as filed: Pomplun, Sebastian Johannes
  2. Edith van der Nol Aachen author as filed: van der Nol, Edith
  3. Böcker, Sebastian
  4. Haupt, Nils Alexander
  5. M. Hoffmann Aachen author as filed: Hoffmann, Martin André

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

  • UNIVERSITEIT LEIDEN GBS Leiden
  • FRIEDRICH-SCHILLER-UNIVERSITÄT JENA
  • BRIGHT GIANT GMBH
  • Univ Jena Friedrich Schiller

Cited papers 4 in the database

Non-patent literature as cited (49)
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Cited patents 1

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