METHODS FOR STEM CELL DIFFERENTIATION
Espacenet
Family 93923044
Abstract
The present invention relates to a method for accelerated and cost-effective generation of insulin-producing beta cells from pluripotent stem cells using a fully defined, small molecule-based differentiation protocol. Further, the present invention relates to a method for obtaining pancreatic endoderm cells from posterior foregut cells. The use of the cells obtained with the method according to the invention is described as well.
Inventors 3
- Elena Naumovska Aachen author as filed: Naumovska, Elena
- Eelco J.P. de Koning Aachen author as filed: de Koning, Eelco J. P.
- Françoise Carlotti Aachen author as filed: Carlotti, Françoise
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden
Cited papers 7 in the database
Non-patent literature as cited (21)
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- - KONDO YASUSHI ET AL: "Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells", DIABETOLOGIA, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 60, no. 8, 22 May 2017 (2017-05-22), pages 1454 - 1466, XP036267630, ISSN: 0012-186X, [retrieved on 20170522], DOI: 10.1007/S00125-017-4302-7
- - LIU HAISONG ET AL: "Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional [beta] cells", vol. 12, no. 1, 1 December 2021 (2021-12-01), XP055935590, Retrieved from the Internet <URL:https://www.nature.com/articles/s41467-021-23525-x.pdf> DOI: 10.1038/s41467-021-23525-x
- - LI JIN ET AL: "Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with small molecules", vol. 14, no. 1, 25 April 2023 (2023-04-25), London, UK, XP093250450, ISSN: 1757-6512, Retrieved from the Internet <URL:https://link.springer.com/article/10.1186/s13287-023-03338-z/fulltext.html> DOI: 10.1186/s13287-023-03338-z