A METHOD FOR PREPARING LIPOSOMES
Espacenet
Family 92208802
Abstract
Method of preparing liposomes comprising the steps of: a) dissolving liposome formulation components, comprising one or more lipids, in a single isotropic monophase solution of polar organic solvent and water; b) freeze drying the solution obtained in step (a), thereby forming a lipid containing formulation cake; and c) hydrating the lipid containing formulation cake, to obtain an aqueous liposome formulation. A kit for preparing cargo-encapsulating liposomes.
Inventors 4
- Koen van der Maaden Aachen author as filed: van der Maaden, Koen
- Ossendorp, Ferdinand Antonius
- Stefan G. Romeijn Aachen author as filed: Romeijn, Stefan Gerard
- A. Rob P.M. Valentijn Aachen author as filed: Valentijn, Adrianus Robertus Petrus Maria
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden
Cited papers 6 in the database
Non-patent literature as cited (18)
- - ZHI ET AL., BIOCONJUGATE CHEMISTRY, vol. 24, 2013, pages 478 - 519
- - SINGLETONSAINSBURY: "Dictionary of Microbiology and Molecular Biology", 1994, JOHN WILEY AND SONS
- - HALEMARHAM: "The Harper Collins Dictionary of Biology", 1991, HARPER PERENNIAL
- - VARYPATAKI ET AL.: "Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines", CANCER IMMUNOL RES, vol. 5, no. 3, 2017, pages 222 - 233
- - WALDMAN ET AL.: "A guide to cancer immunotherapy: from T cell basic science to clinical practice", NATURE REVIEWS IMMUNOLOGY, vol. 20, 2020, pages 651 - 668
- - MAENG ET AL.: "Strategies for developing and optimizing cancer vaccines", F1000RESEARCH, vol. 8, no. F1000 Faculty Rev, 2019, pages 654
- - NELDE: "The Peptide Vaccine of the Future", IMMUNOPEPTIDOMICSI, vol. 20, 2021, pages 100022, XP093036984, DOI: 10.1074/mcp.R120.002309
- - JOSHI ET AL.: "Targeting tumor antigens to dendritic cells using particulate carriers", JOURNAL OF CONTROLLED RELEASE, vol. 161, 10 July 2012 (2012-07-10), pages 25 - 37, XP028493058, DOI: 10.1016/j.jconrel.2012.05.010
- - MA ET AL.: "The role of surface charge density in cationic liposome-promoted dendritic cell maturation and vaccine-induced immune responses", NANOSCALE, 2011
- - VARYPATAKI: "Cationic Liposomes Loaded with a Synthetic Long Peptide and Poly(l:C):a Defined Adjuvanted Vaccine for Induction of Antigen-Specific T Cell Cytotoxicity", AAPS J, vol. 17, 2015, pages 216 - 226, XP035420757, Retrieved from the Internet <URL:https://doi.org/10.1208/s12248-014-9686-4> DOI: 10.1208/s12248-014-9686-4
- - ZHEN ET AL.: "Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes", SCI REP, vol. 11, 2021, pages 7311, Retrieved from the Internet <URL:https://doi.org/10.1038/s41598-021-86484-9>
- - LOMBARDO ET AL.: "Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application", PHARMACEUTICS, vol. 14, no. 3, 2022, pages 543, XP093066778, Retrieved from the Internet <URL:https://doi.org/10.3390/pharmaceutics14030543> DOI: 10.3390/pharmaceutics14030543
- - AKBARZADEH ET AL.: "Liposome: classification, preparation, and applications", NANOSCALE RES LETT, vol. 8, 2013, pages 102, Retrieved from the Internet <URL:https://doi.org/10.1186/1556-276X-8-102>
- - HEUTS ET AL.: "Quantification of Lipid and Peptide Content in Antigenic Peptide-loaded Liposome Formulations by Reversed-phase UPLC using UV Absorbance and Evaporative Light Scattering Detection", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 111, no. 4, April 2022 (2022-04-01), pages 1040 - 1049
- - HEUTS ET AL.: "Cationic Liposomes: A Flexible Vaccine Delivery System for Physicochemically Diverse Antigenic Peptides", PHARM RES, vol. 35, 2018, pages 207, Retrieved from the Internet <URL:https://doi.org.org/10.1007/s11095-018-2490-6>
- [XIY] - VARYPATAKI ELENI MARIA ET AL: "Cationic Liposomes Loaded with a Synthetic Long Peptide and Poly(I:C): a Defined Adjuvanted Vaccine for Induction of Antigen-Specific T Cell Cytotoxicity", THE AAPS JOURNAL, SPRINGER US, BOSTON, vol. 17, no. 1, 12 November 2014 (2014-11-12), pages 216 - 226, XP035420757, DOI: 10.1208/S12248-014-9686-4
- [XIY] - HEUTS JEROEN ET AL: "Cationic Liposomes: A Flexible Vaccine Delivery System for Physicochemically Diverse Antigenic Peptides", PHARMACEUTICAL RESEARCH, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 35, no. 11, 12 September 2018 (2018-09-12), pages 1 - 9, XP036590851, ISSN: 0724-8741, [retrieved on 20180912], DOI: 10.1007/S11095-018-2490-6
- - LOMBARDO DOMENICO ET AL: "Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application", vol. 14, no. 3, 28 February 2022 (2022-02-28), pages 543, XP093066778, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955843/pdf/pharmaceutics-14-00543.pdf> DOI: 10.3390/pharmaceutics14030543