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First published January 30, 2025 Application Aachen patent C – Chemistry & metallurgy

IMPROVED METHOD FOR QUANTIFYING THE CELLULAR COMPOSITION OF A BIOLOGICAL SAMPLE

Espacenet Family 92106643

Abstract (de)

Die Erfindung betrifft ein Verfahren zur Bestimmung zumindest eines Teils der zellulären Zusammensetzung mindestens einer biologischen Probe, die Leukozyten umfasst, wobei der Anteil mindestens eines Leukozytentyps basierend auf den identifizierten Methylierungsgraden bestimmt wird, um die relative Verteilung dieses Leukozytentyps in der Probe vorherzusagen. Die Erfindung betrifft ferner die Verwendung mindestens eines künstlichen Nukleinsäuremoleküls zur Bestimmung zumindest eines Teils der zellulären Zusammensetzung einer biologischen Probe, die Leukozyten umfasst, nach dem oben genannten Verfahren. Im Rahmen der erfindung konnten die folgenden erfindungsgemäßen CpG-Stellen mit zelltypspezifischer Methylierung identifiziert werden: cg22381196 (DHODH), cg12483340 (TMEM87A), cg06270401 (DYRK4), cg23054181 (FAM169BP), cg26076724 (RP11-146I2.2), cg12249234 (KSR1), cg04468741 (MICAL2), cg05074138 (CTLA4), cg05705140 (LINC01237), cg15564619 (SKI), cg11531557 (HMBOX1), cg02212339 (TRPV1), cg22488278 (ZFYVE28), cg02240030 (MAD1L1) und cg24408769 (JARID2).

Inventors 2

  1. Wolfgang Wagner Aachen author as filed: Wagner, Wolfgang
  2. Wouter H. G. Hubens Aachen author as filed: Hubens, Wouter

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

  • Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts RWTH Aachen University

Cited papers 0 in the database

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