CHEMICAL PROBES
Espacenet
Family 91966054
Abstract
Provided is a compound of formula I, or a salt, solvate or precursor thereof as defined herein. Also, pharmaceutical compositions comprising said compounds; combinations of two or more of said compounds; a kits comprising said compounds; the use of said compounds in chemical proteomics; and methods of identifying binding of one or more proteins in a biological sample to one or more of said compounds.
Inventors 4
- van der Stelt, Marcelis
- Joel Rüegger Aachen author as filed: Rüegger, Joel
- Stephan M. Hacker Aachen author as filed: Hacker, Stephan Michael
- Bosman, Robertus Eduardus Johannes
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- UNIVERSITEIT LEIDEN GBS Leiden
Cited papers 9 in the database
Non-patent literature as cited (28)
- - CUESTATAUNTON, ANNU. REV. BIOCHEM., vol. 88, 2019, pages 365 - 81
- - ZANON, P. R. A. ET AL., CHEMRXIV ; CAMBRIDGE: CAMBRIDGE OPEN ENGAGE, 2021
- - PARKERPRATT, CELL, vol. 180, 20 February 2020 (2020-02-20)
- - L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
- - MEISSNER, F.GEDDES-MCALISTER, J.MANN, M. ET AL., NAT REV DRUG DISCOV, vol. 21, 2022, pages 637 - 654
- - CONSORTIUM TUBATEMAN AMARTIN M-J ET AL.: "UniProt: the Universal Protein Knowledgebase", NUCLEIC ACIDS RES, vol. 51, 2022, pages D523 - D531, Retrieved from the Internet <URL:https://doi.org/10.1093/nargkac1052.>
- - BHULLAR, K. S. ET AL.: "Kinase-targeted cancer therapies: progress, challenges and future directions", MOL. CANCER, vol. 17, 2018, pages 48, XP055769399, DOI: 10.1186/s12943-018-0804-2
- - JENNINGS, D. ET AL.: "Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease", SCI. TRANSL. MED., vol. 14, 2022, pages 2658
- - SATO, S. ET AL.: "Essential function for the kinase TAK1 in innate and adaptive immune responses", NAT. IMMUNOL., vol. 6, 2005, pages 1087 - 1095, XP002465094, DOI: 10.1038/ni1255
- - ROSKOSKI, R.: "Properties of FDA-approved small molecule protein kinase inhibitors: A 2024 update", PHARMACOL. RES., vol. 200, 2024, pages 107059
- - COHEN, P.ALESSI, D. R.: "Kinase Drug Discovery - What's Next in the Field?", ACS CHEM. BIOL., vol. 8, 2013, pages 96 - 104
- - FERGUSON, F. M.GRAY, N. S.: "Kinase inhibitors: the road ahead.", NAT. REV. DRUG DISCOV., vol. 17, 2018, pages 353 - 377, XP055757317, DOI: 10.1038/nrd.2018.21
- - KLAEGER, S. ET AL.: "The target landscape of clinical kinase drugs.", SCIENCE, vol. 358, 2017, pages 4368
- - PATRICELLI, M. P. ET AL.: "Functional Interrogation of the Kinome Using Nucleotide Acyl Phosphates.", BIOCHEMISTRY, vol. 46, 2007, pages 350 - 358, XP055241228, DOI: 10.1021/bi062142x
- - SHI, H.ZHANG, C.-J.CHEN, G. Y. J.YAO, S. Q.: "Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes.", J. AM. CHEM. SOC., vol. 134, 2012, pages 3001 - 3014, XP055318803, DOI: 10.1021/ja208518u
- - GREINER, J. V.GLONEK, T.: "Intracellular ATP Concentration and Implication for Cellular Evolution", BIOLOGY, vol. 10, 2021, pages 1166
- - VASTA, J. D. ET AL.: "Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement", CELL CHEM BIOL, vol. 25, 2018, pages 206 - 214
- - SAVITSKI, M. M. ET AL.: "Tracking cancer drugs in living cells by thermal profiling of the proteome.", SCIENCE, vol. 346, 2014, pages 1255784, XP055193718, DOI: 10.1126/science.1255784
- - VASTA, J. D. ET AL.: "Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement", CELL CHEM. BIOL., vol. 25, 2018, pages 206 - 214
- - ROBERS, M. B. ET AL.: "Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET", STAR PROTOC, vol. 2, 2021, pages 100822
- - ZHAO, Q. ET AL.: "Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, 2017, pages 680 - 685, XP055696664, DOI: 10.1021/jacs.6b08536
- - YANG, T. ET AL.: "Reversible lysine-targeted probes reveal residence time-based kinase selectivity.", NAT CHEM BIOL, vol. 1-8, 2022
- - LEUNG, C. O. N. ET AL.: "Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma", NAT. COMMUN., vol. 14, 2023, pages 6699
- - ROODEN, E. J. VAN ET AL.: "Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification.", NAT PROTOC, vol. 13, 2018, pages 752 - 767
- - RAPPSILBER, J.MANN, M.ISHIHAMA, Y.: "Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips", NAT. PROTOC., vol. 2, 2007, pages 1896 - 1906, XP055642417, DOI: 10.1038/nprot.2007.261
- - SKOWRONEK, P. ET AL.: "Rapid and In-Depth Coverage of the (Phospho-)Proteome With Deep Libraries and Optimal Window Design for dia-PASEF", MOL CELL PROTEOMICS, vol. 21, 2022, pages 100279
- - DEMICHEV, V.MESSNER, C. B.VERNARDIS, S. I.LILLEY, K. S.RAISER, M.: "DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput", NAT METHODS, vol. 17, 2020, pages 41 - 44, XP036979562, DOI: 10.1038/s41592-019-0638-x
- - CUESTA ADOLFO ET AL: "Lysine-Targeted Inhibitors and Chemoproteomic Probes", ANNU. REV. BIOCHEM, vol. 88, 11 January 2019 (2019-01-11), pages 365 - 381, XP055772324, DOI: 10.1146/annurev-biochem-061516-