A

ANTICANCER COMPOUNDS

Espacenet Family 91335050

Abstract

Provided herein are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: (I), the substituents of which are as defined herein. Also provided are conjugates of formula (XI), or a pharmaceutically acceptable salt or solvate thereof: (XI), the substituents of which are as defined herein. Also provided are pharmaceutical compositions comprising the compounds or conjugates, as well as use of the compounds or conjugates as a medicament. Also provided are compounds, conjugates or compositions for use in the treatment of cancer. Also provided is the use of the compounds, conjugates or compositions as cytostatic agents.

Inventors 3

  1. Nathaniel I. Martin Aachen author as filed: Martin, Nathaniel Isaac
  2. Meiling Gao Aachen author as filed: Gao, Meiling
  3. Livia Pietrow Aachen author as filed: Pietrow, Livia Maria Anna

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

Cited papers 0 in the database

Non-patent literature as cited (18)
  • - CHASSAGNE ET AL., FRONT. PHARMACOL, vol. 11, 2021
  • - OGISO ET AL., CHEM. PHARM. BULL., vol. 22, no. 1, 1974, pages 135 - 143
  • - SAKATA ET AL., J. PESTICIDE SCI., vol. 2, 1977, pages 453 - 456
  • - GAO ET AL., J. CANCER, vol. 11, no. 17, 2020, pages 5135 - 5149
  • - CRAGG ET AL., ADVANCES IN PHYTOMEDICINE, vol. 1, 2002, pages 23 - 37
  • - BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
  • - E. L. ELIELS. H. WILEN: "Stereochemistry of Organic Compounds", 1994, WILEY
  • - J. MARCH: "Advanced Organic Chemistry", 2013, JOHN WILEY AND SONS
  • - FU ET AL., SIGNAL TRANSDUCTION AND TARGETED THERAPY, vol. 7, 2022, pages 93
  • - SHEYI ET AL., PHARMACEUTICS, vol. 14, 2022, pages 396
  • - SU ET AL., ACTA PHARMACEUTICA SINICA B, vol. 11, no. 12, 2021, pages 3889
  • - HAMBLETT ET AL., CLINICAL CANCER RESEARCH, vol. 10, 2004, pages 7063
  • - DORONINA ET AL., NATURE BIOTECHNOLOGY, vol. 21, no. 7, 2003, pages 778
  • - SU ET AL., ACTA PHARMACEUTICA SINICA 8, vol. 11, no. 12, 2021, pages 3889
  • - HOLLIGERHUDSON, NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 1126 - 1136
  • - GOODMANGILLMAN'S ET AL.: "The Pharmacological Bases of Therapeutics", 2017, MCGRAW-HILL EDUCATION
  • - "Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
  • - OGISO AKIRA ET AL: "The Structure of Toxic Components from Leucothoe Keiskei", 1 January 1974 (1974-01-01), pages 135 - 143, XP093211007, Retrieved from the Internet <URL:https://doi.org/10.1248/cpb.22.135>

Cited patents 1