AGENTS FOR TREATING CELIAC DISEASE
Espacenet
Family 91274739
Abstract
The invention relates to the field of novel chimeric HLA class II molecules. The invention also relates to the field of novel chimeric HLA class II fusion polypeptides, nucleic acids, vectors, modified cells and compositions directed against celiac disease. Associated methods for use in treating and/or preventing celiac disease are also provided herein.
Inventors 4
- Mirjam H.M. Heemskerk Aachen author as filed: Heemskerk, Mirjam H.M.
- Sebastiaan Heidt Aachen author as filed: Heidt, Sebastiaan
- Frits Koning Aachen author as filed: Koning, Frits
- Ilse Gille Aachen author as filed: Gille, Ilse
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden
Cited papers 2 in the database
Non-patent literature as cited (16)
- - SADELAIN ET AL., CANCER DISCOV., vol. 3, no. 4, 2013, pages 388
- - HARRISKRANZ, TRENDS PHARMACOL. SCI., vol. 37, no. 3, 2016, pages 220
- - STONE ET AL., CANCER IMMUNOL. IMMUNOTHER., vol. 63, no. 11, 2014, pages 1163
- - SOLLID LMTYE-DIN JAQIAO SWANDERSON RPGIANFRANI CKONING F: "Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4+ T cells", IMMUNOGENETICS, 18 November 2019 (2019-11-18)
- - R MONJEZI ET AL., LEUKEMIA, 2017
- - ROTH ET AL., NATURE, vol. 559, 2018, pages 405
- - SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY
- - AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1987, JOHN WILEY AND SONS, INC.
- - COHEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
- - LUCHANSKY ET AL., MOL. MICROBIOL., vol. 2, 1988, pages 637 - 646
- - HORN, P.A.: "Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells", BLOOD, vol. 100, no. 12, 2002, pages 3960 - 3967
- - PETERSEN, J. ET AL.: "T-cell receptor recognition of HLA-OQ2-gliadin complexes associated with celiac disease", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 21, no. 5, 2014, pages 480 - 488, XP055343964, DOI: 10.1038/nsmb.2817
- - VADER, W. ET AL.: "The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides", GASTROENTEROLOGY, vol. 122, no. 7, 2002, pages 1729 - 1737, XP002247532
- - DI SABATINO ANTONIO ET AL: "Vaccine Immunotherapy for Celiac Disease", FRONTIERS IN MEDICINE, vol. 5, 26 June 2018 (2018-06-26), XP093224739, ISSN: 2296-858X, DOI: 10.3389/fmed.2018.00187
- - WHITTINGTON KAREN B. ET AL: "CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis", vol. 208, no. 1, 1 January 2022 (2022-01-01), pages 16 - 26, XP093057814, ISSN: 0022-1767, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702470/pdf/nihms-1751337.pdf> DOI: 10.4049/jimmunol.2100643
- - GILLE ILSE ET AL: "Chimeric HLA-antigen receptor (CHAR) Tcell development: A new approach to target HLA sensitization", vol. 99, no. 5, 27 April 2022 (2022-04-27), Hoboken, USA, pages 416 - 550, XP093224880, ISSN: 2059-2302, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full-xml/10.1111/tan.14606> DOI: 10.1111/tan.14606