A

Disease Model

Espacenet Family 88517590

Abstract

[0001] The present invention provides a method for producing an arrhythmia disease model. lt also provides a corresponding arrhythmia disease model or arrhythmia disease model system. The arrhythmia disease model or arrhythmia disease model system may be used to screen for 5 compounds that have the ability to treat arrhythmia. Methods of screening one or more test compounds for treating arrhythmia using the model or system are therefore also provided.

Inventors 4

  1. Richard, Paul Frank Davis
  2. Tessa, de Korte
  3. Benjamin, Blakeley Johnson
  4. Christine, Lindsay Mummery

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

  • ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden

Cited papers 3 in the database

Non-patent literature as cited (12)
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  • - GIACOMELLI, E. ET AL.: "Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease", CELL STEM CELL, vol. 26, 2020, pages 862 - 879
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  • - SANDEEP S HOTHI ET AL: "Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart", PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY, SPRINGER, BERLIN, DE, vol. 457, no. 2, 4 July 2008 (2008-07-04), pages 253 - 270, XP019657968, ISSN: 1432-2013, DOI: 10.1007/S00424-008-0508-3

Cited patents 0