A
Menu
First published February 29, 2024 Application Aachen patent A – Human necessities

TOXIN-BINDER FOR HEMODIALYSIS

Espacenet Family 87929986

Abstract (de)

Die Erfindung betrifft neue Toxin-Bindemittel für die Hämodialyse. Die Erfindung stellt ein Apoferritin-Nanopartikel zur Anwendung als Toxin-Bindemittel bei der Hämodialyse bereit, wobei das Apoferritin-Nanopartikel Apoferritin-Untereinheiten umfasst, die zu dem Apoferritin-Nanopartikel zusammengesetzt einen inneren Hohlraum ausbilden, und wobei das Apoferritin-Nanopartikel in seinem inneren Hohlraum keine Nanopartikel enthält. Darüber hinaus stellt die Erfindung eine Zusammensetzung, eine Sorptionskartusche sowie ein Dialysesystem bereit.

Inventors 4

  1. Tobias Beck Aachen author as filed: Beck, Tobias
  2. Böhler, Hendrik
  3. Joachim Jankowski Aachen author as filed: Jankowski, Joachim
  4. Setareh Orth-Alampour Aachen author as filed: Orth-Alampour, Setareh

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

  • Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts RWTH Aachen University
  • Universität Hamburg, Körperschaft des öffentlichen Rechts
  • Univ Hamburg Koerperschaft Des Oeffentlichen Rechts
  • Universität Hamburg
  • Univ Hamburg

Cited papers 0 in the database

Non-patent literature as cited (39)
  • - Bikbov, B. et al., 2020, Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017, The Lancet 395, 709 - 733
  • - Schlieper, G., Hess, K, Floege J., Marx, N., 2016, The vulnerable patient with chronic kidney disease, Nephrology Dialysis Transplantation 31, 382-390
  • - Ito, S.; Yoshida, M. Protein-Bound Uremic Toxins: New Culprits of Cardiovascular Events in Chronic Kidney Disease Patients. Toxins 2014, 6, 665-678
  • - Karbowska, M.; Kaminski, T.W.; Marcinczyk, N.; Misztal, T.; Rusak, T.; Smyk, L.; Pawlak, D. The Uremic Toxin Indoxyl Sulfate Accelerates Thrombotic Response after Vascular Injury in Animal Models. Toxins 2017, 9, 229
  • - Dou L., Bertrand, E., Cerini, C., Faure, V., Sampol, J., Vanholder, R., Berland, Y" Brunet, P., 2004, The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair, Kidney International 65, 442-451
  • - Lekawanvijit, S., Kompa, A.R., Krum, H., 2016, Protein-bound uremic toxins: a long overlooked culprit in cardiorenal syndrome, Am J Physiol Renal Physiol 311: F52-F62
  • - Sun CY, Chang SC, Wu MS (2012) Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin-Angiotensin-Aldosterone System Associated Epithelial-to-Mesenchymal Transition. PLOS ONE 7(3): e34026
  • - Yu M, Kim, YJ, Kang, D-H, 2011, Indoxyl Sulfate-Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative Stress, CJASN 6, 30-39
  • - Liabeuf, S., Barreto, D.V., Barreto, F.C., Meert, N., Glorieux, G., Schepers, E., Temmar, M., Choukroun, G., Vanholder, R., Massy, Z.A., on behalf of the European Uraemic Toxin Work Group (EUTox), 2010, Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease, Nephrology Dialysis Transplantation 25, 1183-1191
  • - Bammens, B., Evenepoel, P., Keuleers, H., Verbeke, K., Vanrenterghem Y., 2006, Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients, Kidney International 69, 1081-1087
  • - Sirich, T.L., Fong, K., Larive, B., Beck, G.J., Chertow, G.M., Levin, N.W., Kliger, A.S., Plummer, N.S., Meyer, T.W., 2017, Limited reduction in uremic solute concentrations with increased dialysis frequency and time in the Frequent Hemodialysis Network Daily Trial, Kidney International 91, 1186-1192
  • - Vanholder, R., De Smet, R., Glorieux, G., Argilés, A., Baurmeister, U., Brunet, P., Clark, W., Cohen, G., De Deyn, P.P., Deppisch, R., Descamps-Latscha, B., Henle, T., Jörres, A,. Lemke, H.D., Massy, Z.A., Passlick-Deetjen, J., Rodriguez, M., Stegmayr, B., Stenvinkel, P., Tetta, C., Wanner, C., Zidek, W., 2003, For the European Uremic Toxin Work Group (EUTox), Review on uremic toxins: Classification, concentration, and interindividual variability, Kidney International 63, 1934-1943
  • - Jansen, J., Jankowski, J., Gajjala, P.R., Wetzels, J.F.M., Masereeuw, R., 2017, Disposition and clinical implications of protein-bound uremic toxins, Clin Sci (Lond) 131, 1631-1647
  • - Itoh, Y., Ezawa, A., Kikuchi, K. et al. Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production. Anal Bioanal Chem 403, 1841-1850
  • - Madero, M., Cano, K.B., Campos, I., Tao, X., Maheshwari, V., Brown, J., Cornejo, B., Handelman, G., Thijssen, S., Kotanko, P., 2019, Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor, CJASN 14, 394-402
  • - Urquhart, B.L., Freeman, D.J., Spence, J.D., House, A.A., 2006, The Effect of Mesna on Plasma Total Homocysteine Concentration in Hemodialysis Patients, American Journal of Kidney Diseases, Volume 49, Issue 1, 109-117
  • - Perna, A.F., Violetti, E., Lanza, D., Sepe, I., Bellinghieri, G., Savica, V., Santoro, D., Satta, E., Cirillo, G., Lupo A., Abaterusso, C., Raiola, I., Raiola, P., Coppola, S., Di Iorio, B., Tirino, G., Cirillo, M., Ingrosso, D., De Santo, N.G., 2012, Therapy of Hyperhomocysteinemia in Hemodialysis Patients: Effects of Folates and N-Acetylcysteine, Journal of Renal Nutrition 22, 507-514.e1
  • - Yamamoto, S., Kazama, J., Omori, K. et al. Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients. Sci Rep 5, 14381
  • - Rocchetti, M.T.; Cosola, C.; di Bari, I.; Magnani, S.; Galleggiante, V.; Scandiffio, L.; Dalfino, G.; Netti, G.S.; Atti, M.; Corciulo, R.; Gesualdo, L. Efficacy of Divinylbenzenic Resin in Removing Indoxyl Sulfate and P-cresol Sulfate in Hemodialysis Patients: Results from an In Vitro Study and an In Vivo Pilot Trial (xuanro4-Nature 3.2). Toxins 2020, 12, 170
  • - Saar-Kovrov, V, Zidek, W, Orth-Alampour, S, Fliser, D, Jankowski, V, Biessen, EAL, Jankowski, J (University hospital, Aachen, Germany; Maastricht University Medical Center, Maastricht, the Netherlands; Charite - Universitätsmedizin Berlin, Berlin, Germany; Saarland University Medical Center, Homburg, Germany). Reduction of protein-bound uraemic toxins in plasma of chronic renal failure patients: A systematic review (Review). J Intern Med 2021; 290: 499- 526
  • - Brettschneider, F., Tölle, M., von der Giet, M., Passlick-Deetjen, J., Steppan, S., Peter, M., Jankowski, V., Krause, A., Kühne, S., Zidek, W. and Jankowski, J. (2013), Thoughts and Progress. Artificial Organs, 37: 409-416
  • - Falkenhagen, D., Strobl, W., Vogt, G., Schrefl, A., Linsberger, I., Gerner, F.J. and Schoenhofen, M. (1999), Fractionated Plasma Separation and Adsorption System: A Novel System for Blood Purification to Remove Albumin Bound Substances. Artificial Organs, 23: 81-86
  • - Sternkopf, M.; Thoröe-Boveleth, S.; Beck, T.; Oleschko, K.; Erlenkötter, A.; Tschulena, U.; Steppan, S.; Speer, T.; Goettsch, C.; Jankowski, V.; Jankowski, J.; Noels, H.; The European Uremic Toxin Work Group-EUTox. A Bifunctional Adsorber Particle for the Removal of Hydrophobie Uremic Toxins from Whole Blood of Renal Failure Patients. Toxins 2019, 11, 389
  • - Kato, S., Otake, K., Chen, H., Akpinar, I., Buru, C.T., Islamoglu, T., Snurr, R.Q., Farha, O.K., 2019, Zirconium-Based Metal-Organic Frameworks for the Removal of Protein-Bound Uremic Toxin from Human Serum Albumin, Journal of the American Chemical Society 141, 2568-2576
  • - Berge-Lefranc, D., Vagner, C., Calaf, R., Denoyel, R., Brunet, P., Ghobarkar, H., Schaf, O., 2012, In vitro elimination of protein bound uremic toxin p-cresol by MFI-type zeolites. Microporous and Mesoporous Materials 153, 288-293
  • - Barreto, F.C., Barreto, D.V., Liabeuf, S., Meert, N., Glorieux, G., Temmar, M., Choukroun, G., Vanholder, R., Massy, Z.A., on behalf of the European Uremic Toxin Work Group (EUTox), 2009, Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients, CJASN 4 (10) 1551-1558
  • - Rifai K, Ernst T, Kretschmer U, Bahr MJ, Schneider A, Hafer C, Haller H, Manns MP, Fliser D. Prometheus--a new extracorporeal system for the treatment of liver failure. J Hepatol. 2003 Dec;39(6):984-90. doi: 10.1016/s0168-8278(03)00468-9
  • - Zhang, C.; Zhang, X.; Zhao, G. Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine. Nanomaterials 2020, 10, 1894
  • - Hempstead PD, Yewdall SJ, Fernie AR, Lawson DM, Artymiuk PJ, Rice DW, Ford GC, Harrison PM. Comparison of the three-dimensional structures of recombinant human Hand horse L ferritins at high resolution. J Mol Biol. 1997 May 2;268(2):424-48
  • - Wang W, Malcolm BA. Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed Mutagenesis. Biotechniques. 1999 Apr;26(4):680-2
  • - Künzle, M., Eckert, T., Beck T., 2016, Binary Protein Crystals for the Assembly of Inorganic Nanoparticle Superlattices, J. Am. Chem. Soc. 138, 12731-12734
  • - Rayment, I., 2002, Small-Scale Batch Crystallization of Proteins Revisited: An Underutilized Way to Grow Large Protein Crystals, Structure 10, 147-151
  • - Hida M, Aiba Y, Sawamura S, Suzuki N, Satoh T, Koga Y. Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis. Nephron. 1996;74(2):349-55
  • - Jankowski J., van der Giet M., Jankowski, V., Schmidt, S., Hemeier, M., Mahn, B., Giebing, G., Tölle, M., Luftmann, H., Schlüter, H., Zidek, W., Tepel M., 2003, Increased plasma phenylacetic acid in patients with end-stage renal failure inhibits iNOS expression, J Clin Invest. 112(2):256-264
  • - Lu L., Yeow J.T.W. An adsorption study of indoxyl sulfate by zeolites and polyethersulfone-zeolite composite Mater 2017;120:328-335
  • - Pavlenko, D., Giasafaki, D., Charalambopoulou, G. et al. Carbon Adsorbents With Dual Porosity for Efficient Removal of Uremic Toxins and Cytokines from Human Plasma. Sci Rep 7, 14914
  • - van Gelder MK, Middel IR, Vernooij RWM, Bots ML, Verhaar MC, Masereeuw R, Grooteman MP, Nube MJ, van den Dorpel MA, Blankestijn PJ, Rookmaaker MB, Gerritsen KGF, 2020, Protein-Bound Uremic Toxins in Hemodialysis Patients Relate to Residual Kidney Function, Are Not Influenced by Convective Transport, and Do Not Relate to Outcome, Toxins 12(4):234
  • - Kim, M., Rho, Y., Jin, K.S., Ahn, B., Jung, S., Kim, H., Ree, M., 2011, pH-Dependent Structures of Ferritin and Apoferritin in Solution: Disassembly and Reassembly, Biomacromolecules 2011, 12, 5, 1629-1640
  • - Liu, X., Jin, W., Theil, E.C., 2003, Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral, PNAS 100, 3653-3658

Cited patents 2

DE102016108017A1 WO2004001019A2