A

Cytotoxic agent

Espacenet Family 86851764

Abstract

Provided is a cytotoxic agent which is activatable by exposure to light. The agent comprises a metal cluster and a molecule comprising a photocleavable group. The molecule forms a structure which at least partially encloses the metal cluster so as to prevent the metal cluster from interacting with a surrounding environment and wherein, upon exposure to light, cleavage of the photocleavable group changes the structure of the molecule such that the metal cluster is able to interact with the surrounding environment.

Inventors 8

  1. Donny, de Bruin
  2. Doris, Marianne Heinrich
  3. Dirk, Bouwmeester
  4. Debruyne, Donny
  5. Baumeister, Dirk
  6. Doris Heinrich Aachen author as filed: Heinrich, Doris Marianne
  7. Donny de Bruin Aachen author as filed: de Bruin, Donny
  8. Dirk Bouwmeester Aachen author as filed: Bouwmeester, Dirk

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

Cited papers 3 in the database

Non-patent literature as cited (9)
  • - WU TIANTIAN ET AL: "Self-assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic-resistant bacteria", AGGREGATE, 7 August 2023 (2023-08-07), XP093095647, ISSN: 2692-4560, DOI: 10.1002/agt2.402
  • - LIN XI ET AL: "A cytosine-rich hairpin DNA loaded with silver nanoclusters as a fluorescent probe for uranium(IV) and mercury(II) ions", MICROCHIMICA ACTA, vol. 186, no. 8, XP037362491, ISSN: 0026-3672, DOI: 10.1007/S00604-019-3625-0
  • - DE BRUIN DONNY ET AL: "Measuring DNA hybridization using fluorescent DNA-stabilized silver clusters to investigate mismatch effects on therapeutic oligonucleotides", JOURNAL OF NANOBIOTECHNOLOGY, vol. 16, no. 1, 6 April 2018 (2018-04-06), XP093095853, Retrieved from the Internet <URL:http://link.springer.com/content/pdf/10.1186/s12951-018-0361-2.pdf> DOI: 10.1186/s12951-018-0361-2
  • - BROWN PAIGE K. ET AL: "Silver Nanoscale Antisense Drug Delivery System for Photoactivated Gene Silencing", ACS NANO, vol. 7, no. 4, 25 March 2013 (2013-03-25), US, pages 2948 - 2959, XP093098921, ISSN: 1936-0851, DOI: 10.1021/nn304868y
  • - ROLBAND LEWIS ET AL: "DNA-Templated Fluorescent Silver Nanoclusters Inhibit Bacterial Growth While Being Non-Toxic to Mammalian Cells", MOLECULES, vol. 26, no. 13, 1 July 2021 (2021-07-01), pages 4045, XP093098526, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271471/pdf/molecules-26-04045.pdf> DOI: 10.3390/molecules26134045
  • - DANAI LEYLA ET AL: "Optical, structural and antibacterial properties of silver nanoparticles and DNA-templated silver nanoclusters", NANOMEDICINE, vol. 18, no. 9, 1 April 2023 (2023-04-01), GB, pages 769 - 782, XP093095650, ISSN: 1743-5889, Retrieved from the Internet <URL:http://dx.doi.org/10.2217/nnm-2023-0082> DOI: 10.2217/nnm-2023-0082
  • - XU LI ET AL: "Silver nanoparticles: Synthesis, medical applications and biosafety", THERANOSTICS, vol. 10, no. 20, 11 July 2020 (2020-07-11), AU, pages 8996 - 9031, XP093098756, ISSN: 1838-7640, Retrieved from the Internet <URL:https://www.thno.org/v10p8996.pdf> DOI: 10.7150/thno.45413
  • - O'HAGAN MICHAEL P. ET AL: "Photocleavable Ortho -Nitrobenzyl-Protected DNA Architectures and Their Applications", CHEMICAL REVIEWS, vol. 123, no. 10, 20 April 2023 (2023-04-20), US, pages 6839 - 6887, XP093095646, ISSN: 0009-2665, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.3c00016> DOI: 10.1021/acs.chemrev.3c00016
  • - ZHAO B ET AL: "DNA-collagen complex as a carrier for Ag^+ delivery", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, ELSEVIER BV, NL, vol. 37, no. 3, 15 November 2005 (2005-11-15), pages 143 - 147, XP027766814, ISSN: 0141-8130, [retrieved on 20051115]

Cited patents 1