4-HYDROXYPHENYLPYRUVATE DIOXYGENASE VARIANTS
Espacenet
Family 86605033
Abstract
The present invention relates to recombinant variants of the human 4-hydroxyphenylpyruvate dioxygenase (HPD) enzyme that have a decreased sensitivity to an HPD inhibitor. The invention also relates to their use in clinical applications to treat tyrosine metabolism related diseases.
Inventors 5
- de Kock, Joery
- Neuckermans, Jessie
- Vanhaecke, Tamara
- Ulrich Schwaneberg Aachen author as filed: Schwaneberg, Ulrich
- Gaurao V. Dhoke Aachen author as filed: Dhoke, Gaurao
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- VRIJE UNIVERSITEIT BRUSSEL
- RWTH AACHEN UNIVERSITY RWTH Aachen University
- Univ Brussel Vrije
Cited papers 0 in the database
Non-patent literature as cited (7)
- - YIN ET AL., BIOTECHNOLOGY, vol. 32, 2014, pages 551 - 3
- - NEUCKERMANS JESSIE ET AL: "Directed protein evolution as a tool to innovate gene therapy for hereditary tyrosinemia type 1", vol. 73, no. Suppl. 1, 31 August 2020 (2020-08-31), pages S543 - S543, XP093091621, Retrieved from the Internet <URL:https://www.journal-of-hepatology.eu/article/S0168-8278(20)31559-2/pdf>
- - NICOLAS CLARA T. ET AL: "In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions", vol. 13, no. 1, 25 August 2022 (2022-08-25), XP093091657, Retrieved from the Internet <URL:https://www.nature.com/articles/s41467-022-32576-7> DOI: 10.1038/s41467-022-32576-7
- - LIU YONG-XUAN ET AL: "Identification of key residues determining the binding specificity of human 4-hydroxyphenylpyruvate dioxygenase", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 154, 1 November 2020 (2020-11-01), NL, pages 105504, XP093091080, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2020.105504
- - PANKOWICZ FRANCIS P. ET AL: "Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia", vol. 7, no. 1, 30 August 2016 (2016-08-30), pages 1 - 6, XP055951540, Retrieved from the Internet <URL:http://www.nature.com/articles/ncomms12642> DOI: 10.1038/ncomms12642
- - GU PENG ET AL: "Genetically blocking HPD via CRISPR-Cas9 protects against lethal liver injury in a pig model of tyrosinemia type I", MOLECULAR THERAPY- METHODS & CLINICAL DEVELOPMENT, vol. 21, 9 April 2021 (2021-04-09), GB, pages 530 - 547, XP055951536, ISSN: 2329-0501, DOI: 10.1016/j.omtm.2021.04.002
- - DATABASE EBI GSP [online] 1 December 2022 (2022-12-01), CAMERON E A: "Callithrix jacchus beta-HIV synthase, SEQ ID 126.", XP093091628, Database accession no. GSP:BLX14078 * abstract *