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First published October 12, 2023 Application Aachen patent A – Human necessities

EPITHELIAL CELL ADHESION MOLECULE (EPCAM)-FLUORESCENCE IMAGING MOLECULE FOR THE DETECTION OF GASTROINTESTINAL TUMORS AND CANCER POSITIVE LYMPH NODES

Espacenet Family 86142939

Abstract

Herein is provided a novel molecule and infusion solutions containing the molecule useful for the detection and imaging of EpCAM positive tumors as well as lymph nodes, such as, but not limited to, lower GI (i.e. colorectal) and upper GI (i.e. gastric and esophageal) cancers. The molecule is comprised of an antibody or antibody fragment capable of specifically targeting EpCAM conjugated to a NIR fluorescent dye. A preferred antibody fragment is VB5-845D and a preferred NIR fluorescent dye is IRDye 800CW. Aspects of the invention provide a method of intraoperative tumor visualization of EpCAM expressing primary tumors and lymph nodes.

Inventors 3

  1. Alexander L. Vahrmeijer Aachen author as filed: Vahrmeijer, Alexander Lucas
  2. Cornelis F.M. Sier Aachen author as filed: Sier, Cornelis Frederikus Maria
  3. Kuppen, Petrus Johannes Karel

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

  • ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC GBS Leiden

Cited papers 13 in the database

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Cited patents 1

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