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First published September 11, 2023 Granted Aachen patent A – Human necessities

DHCR24 INHIBITORY COMPOUNDS

Espacenet Family 82100159

Abstract

[0206] The present disclosure relates to compounds suitable for the inhibition of A24- dehydrocholesterol reductase (DHCR24), particularly the selective inhibition of DHCR24. These compounds are for use as therapeutic agents, in particular, agents for use in the treatment and/or prevention of a DHCR24-mediated disorder, such as non-alcoholic hepatosteatitis (NASH), atherosclerotic cardiovascular disease (asCVD) or multiple sclerosis (MS).

Inventors 11

  1. Patrick, Cornelis Nicolaas Rensen
  2. Martin, Andreas Giera
  3. Christoph, Anton Müller
  4. Franz, Bracher
  5. Blacher, Franz
  6. Gila, Martin Andreas
  7. M, Ller Christoph Anton
  8. Patrick C.N. Rensen Aachen author as filed: Rensen, Patrick Cornelis Nicolaas
  9. Bracher, Franz
  10. Martin A. Giera Aachen author as filed: Giera, Martin Andreas
  11. Müller, Christoph Anton

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

  • ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden
  • 莱顿教学医院

Cited papers 2 in the database

Non-patent literature as cited (24)
  • - L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
  • - "Methods in Enzymology", vol. 42, 1985, ACADEMIC PRESS, pages: 309 - 396
  • - H. BUNDGAARD: "A Textbook of Drug Design and Development", 1991, article "Design and Application of Pro-drugs", pages: 113 - 191
  • - H. BUNDGAARD, ADVANCED DRUG DELIVERY REVIEWS, vol. 8, 1992, pages 1 - 38
  • - H. BUNDGAARD ET AL., JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 77, 1988, pages 285
  • - N. KAKEYA ET AL., CHEM. PHARM. BULL., vol. 32, 1984, pages 692
  • - T. HIGUCHIV. STELLA: "Pro-Drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
  • - "Bioreversible Carriers in Drug Design", 1987, PERGAMON PRESS
  • - NATURE NEUROSCIENCE, vol. 24, no. 1, 2021, pages 47 - 60
  • - BRITISH JOURNAL OF CANCER,, vol. 123, 2000, pages 1673 - 1685
  • - CANCER SCI., vol. 111, no. 10, 2020, pages 3653 - 3664
  • - BLOOD, vol. 139, no. 1, 2022, pages 73 - 86
  • - FRONT. ONCOL., 2 December 2021 (2021-12-02), Retrieved from the Internet <URL:https://doi.org/10.3389/fonc.2021.704024>
  • - J. HEPATOL., vol. 55, no. 3, 2011, pages 512 - 521
  • - C. MULLER ET AL., EUR. J. MED. CHEM., vol. 140, 2017, pages 305 - 320
  • - SANDRA HEMMERS: "Seitenkettenfunktionalisierte Steroide als Inhibitoren der Ergosterol- und Cholesterolbiosynthese", PHD THESIS, 2012
  • - D. RENARD ET AL., BIOORG. MED. CHEM.,, vol. 17, 2009, pages 8123 - 8137
  • - MULLER ET AL., NATURE PROTOCOLS, vol. 14, no. 8, 2019, pages 2546 - 2570
  • - MÜLLER CHRISTOPH ET AL: "Dehydrocholesterol Reductase 24 (DHCR24): Medicinal Chemistry, Pharmacology and Novel Therapeutic Options", vol. 29, no. 23, 14 January 2022 (2022-01-14), NL, pages 4005 - 4025, XP055973638, ISSN: 0929-8673, Retrieved from the Internet <URL:https://www.eurekaselect.com/197928/article> DOI: 10.2174/0929867328666211115121832
  • [XDI] - MÜLLER CHRISTOPH ET AL: "New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 140, 10 November 2017 (2017-11-10), pages 305 - 320, XP085227224, ISSN: 0223-5234, DOI: 10.1016/J.EJMECH.2017.08.011
  • - DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1 December 2020 (2020-12-01), ZHOU E ET AL: "[Delta]24-Dehydrocholesterol reductase (DHCR24): A novel target for the treatment of nash", Database accession no. EMB-002010440836 * abstract *
  • - ZHOU E ET AL: "[Delta]24-Dehydrocholesterol reductase (DHCR24): A novel target for the treatment of nash", ATHEROSCLEROSIS 20201201 ELSEVIER IRELAND LTD NLD, vol. 315, 1 December 2020 (2020-12-01), pages e11 CONF 20201004 to 20201004 Virtual, Online - EAS 2020, ISSN: 0021-9150
  • - ZHOU E ET AL: "[Delta]24-Dehydrocholesterol reductase (DHCR24): A novel target for the treatment of NASH", 1 December 2020 (2020-12-01), pages 1 - 1, XP093289959, Retrieved from the Internet <URL:https://pdf.sciencedirectassets.com/271064/1-s2.0-S0021915020X00220/1-s2.0-S0021915020306298/main.pdf?hash=abdc2c0e5da0ac498caa0a980bc96cbaa22cc95e41ac08e0671ba3e040869db4&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0021915020306298&tid=spdf-5c1feef7-4e74-41f3-b2e7-07c> [retrieved on 20250626]
  • - DESIRÉE HEERDEGEN ET AL: "Synthesis of Seco-Analogues of the DHCR24 Inhibitor SH-42", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2020, no. 39, 24 September 2020 (2020-09-24), pages 6270 - 6288, XP072124590, ISSN: 1434-193X, DOI: 10.1002/EJOC.202001080

Cited patents 0