A

METHOD FOR INCREASING THE SELECTIVITY OF A MEMBRANE

Espacenet Family 79018879

Abstract

The disclosure relates to a method for improving the selectivity of a membrane, specifically of a membrane comprising a blend of i) a polysulfone, polyethersulfone or polyarylethersulfone and ii) polyvinylpyrrolidone, characterized in that the membrane is coated with polydopamine and heparin in a one-step or two-step reaction or by in situ modification with polydopamine followed by coating with heparin. The disclosure further relates to a process for producing such modified membranes having an improved selectivity, and to a filtration/diffusion device comprising the membrane which can be used, for example, in hemodialysis applications.

Inventors 11

  1. Hannah Roth Aachen author as filed: Roth, Hannah
  2. Georg Linz Aachen author as filed: Linz, Georg
  3. Ilka I. Rose Aachen author as filed: Rose, Ilka
  4. Matthias Weßling Aachen author as filed: Wessling, Matthias
  5. Lars Peters Aachen author as filed: Peters, Lars
  6. KRAUß, Annabelle
  7. Hulko, Michael
  8. Hornung, Markus
  9. Votteler, Stefanie
  10. Storr, Markus
  11. Swartjes, Jan J.T.M.

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

Cited papers 4 in the database

Non-patent literature as cited (25)
  • - BOSCHETTI-DE-FIERRO ET AL., SCIENTIFIC REPORTS, vol. 5, 2015, pages 18448
  • - ROSNER ET AL., CLASSIFICATION OF UREMIC TOXINS AND THEIR ROLE IN KIDNEY FAILURE: CJASN, vol. 16, 2021, pages 1 - 8
  • - LORENZ ET AL., KIDNEY INTERNATIONAL, vol. 93, 2018, pages 221 - 230
  • - KIRSCH ET AL., NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 32, 2017, pages 165
  • - LIEBSCHER: "Chemistry of Polydopamine - Scope, Variation, and Limitation", EUR. J. ORG. CHEM., no. 2019, 2019, pages 4976 - 4994, XP055846824, DOI: 10.1002/ejoc.201900445
  • - LI ET AL., DESALINATION, vol. 344, 2014, pages 422 - 430
  • - ZHU ET AL., SURFACE MODIFICATION OF PVDF POROUS MEMBRANES VIA POLY(DOPA) COATING AND HEPARIN IMMOBILIZATION, COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 69, no. 1, 2009, pages 152 - 155
  • - WHILE JIANG ET AL.: "Surface modification of PE porous membranes based on the strong adhesion of polydopamine and covalent immobilization of heparin", JOURNAL OF MEMBRANE SCIENCE, vol. 364, no. 1-2, 2010, pages 194 - 202, XP027450293, DOI: 10.1016/j.memsci.2010.08.017
  • - YOU ET AL.: "Enhancement of blood compatibility of poly (urethane) substrates by mussel-inspired adhesive heparin coating", BIOCONJUGATE CHEMISTRY, vol. 22, no. 7, 2011, pages 1264 - 1269
  • - GAO ET AL., JOURNAL OF MEMBRANE SCIENCE, vol. 452, 2014, pages 390 - 399
  • - MA ET AL.: "Mussel-inspired self-coating at macro-interface with improved biocompatibility and bioactivity via dopamine grafted heparin-like polymers and heparin", JOURNAL OF MATERIALS CHEMISTRY B, vol. 2, 2014, pages 363 - 375
  • - RONCOCLARK: "Nature Reviews", NEPHROLOGY, vol. 14, no. 6, 2018, pages 394 - 410
  • - GONDOUINHUTCHISON: "High Cut-Off Dialysis Membranes: Current Uses and Future Potential", ADVANCES IN CHRONIC KIDNEY DISEASE, vol. 18, 2011, pages 180 - 187
  • - ROSNER ET AL.: "Classification of Uremic Toxins and Their Role in Kidney Failure", CLIN J AM SOC NEPHROL, 2021
  • - SALOMAKI ET AL., J. PHYS. CHEM. B, vol. 122, 2018, pages 6314 - 6327
  • - LANER-PLAMBERGER ET AL., INT. J. MOL. SCI., vol. 22, 2021, pages 12041
  • - SAID ET AL.: "A Review of Commercial Developments and Recent Laboratory Research of dialyzers and Membranes for Hemodialysis Application", MEMBRANES, vol. 11, 2021, pages 767
  • - SMITH ET AL., ANALYTICAL BIOCHEMISTRY, vol. 150, 1985, pages 76 - 85
  • - LAMMERS ET AL.: "A comparison of seven methods to analyze heparin in biomaterials: quantification, location, and anticoagulant activity", TISSUE ENG PART C METHODS, vol. 17, no. 6, 2011, pages 669 - 76
  • - NEWALL F: "Anti-factor Xa (anti-Xa) assay", METHODS MOL BIOL, vol. 992, 2013, pages 265 - 72
  • [XIY] - XIE BINGWU ET AL: "A Decoration of heparin and bovine serum albumin on polysulfone membrane assisted via polydopamine strategy for hemodialysis", vol. 27, no. 9, 12 June 2016 (2016-06-12), pages 880 - 897, XP009535996, ISSN: 0920-5063, Retrieved from the Internet <URL:http://www.tandfonline.com/doi/full/10.1080/09205063.2016.1169479> [retrieved on 20160422], DOI: 10.1080/09205063.2016.1169479
  • [XIY] - GAO AILIN ET AL: "Preparation and evaluation of heparin-immobilized poly (lactic acid) (PLA) membrane for hemodialysis", JOURNAL OF MEMBRANE SCIENCE, vol. 452, 1 February 2014 (2014-02-01), NL, pages 390 - 399, XP55926240, ISSN: 0376-7388, DOI: 10.1016/j.memsci.2013.10.016
  • [DXI] - MA ET AL.: "Mussel-inspired self-coating at macro-interface with improved biocompatibility and bioactivity via dopamine grafted heparin-like polymers and heparin", JOURNAL OF MATERIALS CHEMISTRY B, vol. 2, 2014, pages 363 - 375, XP002806663
  • [YXI] - JIANG J H ET AL: "Surface modification of PE porous membranes based on the strong adhesion of polydopamine and covalent immobilization of heparin", JOURNAL OF MEMBRANE SCIENCE, ELSEVIER BV, NL, vol. 364, no. 1-2, 15 November 2010 (2010-11-15), pages 194 - 202, XP027450293, ISSN: 0376-7388, [retrieved on 20100814], DOI: 10.1016/J.MEMSCI.2010.08.017
  • - GAO AILIN ET AL: "Preparation and evaluation of heparin-immobilized poly (lactic acid) (PLA) membrane for hemodialysis", JOURNAL OF MEMBRANE SCIENCE, vol. 452, 1 February 2014 (2014-02-01), pages 390 - 399, XP055926240, DOI: 10.1016/j.memsci.2013.10.016