OLIGONUCLEOTIDE FOR INHIBITING QUAKING ACTIVITY

Abstract

[0001] The invention relates to the field of oligonucleotides that can inhibit a RNA-binding protein (RBP) such as Quaking (QKI) by acting as a binding sequence for said RBP ("decoys"). Such oligonucleotide may be used for the treatment of any disease or condition associated with an elevated expression level of QKI, such as inflammation or fibrosis. [0002] L'invention concerne le domaine des oligonucléotides qui peuvent inhiber une protéine de liaison à l'ARN (RBP) comme le tremblement (QKI) en agissant en tant que séquence de liaison pour ladite RBP ("leurres"). Un tel oligonucléotide peut être utilisé pour le traitement de toute maladie ou affection associée à un niveau d'expression élevé de QKI, tel que l'inflammation ou la fibrose.

Inventors 6

1. Anton Jan van Zonneveld Aachen author as filed: van Zonneveld, Anton Jan
2. Ruben G. de Bruin Aachen author as filed: de Bruin, Ruben Gosewinus
3. Jurriën Prins Aachen author as filed: Prins, Jurrien
4. Wagenaar, Gerardus Theodorus Marie
5. Wachowius, Falk
6. van der Veer, Eric Peter

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

• ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. GBS Leiden

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