T CELL RECEPTORS DIRECTED AGAINST BOB1 AND USES THEREOF
Abstract
[0001] Novel nucleic acid compositions, vector systems, modified cells and pharmaceutical compositions that encode or express T cell receptor components directed against Bob1 are provided herein. These novel components may be used to enhance an immune response in a subject diagnosed with a hyperproliferative disease or condition. Associated methods for treating such subjects are therefore also provided herein. [0002] L'invention concerne de nouvelles compositions d'acides nucléiques, des systèmes de vecteurs, des cellules modifiées et des compositions pharmaceutiques codant ou exprimant des composants de récepteur de lymphocytes T dirigés contre Bob1. Ces nouveaux composants peuvent être utilisés pour améliorer une réponse immunitaire chez un sujet diagnostiqué comme ayant une maladie ou une affection hyperproliférative. L'invention concerne en outre des méthodes associées pour traiter de tels sujets.
Inventors 4
- Heemskerk, Mw Mirjam H. M.
- Falkenburg, de Heer J. H. Frederik
- Mirjam H.M. Heemskerk Aachen author as filed: Heemskerk, Mirjam H.M.
- J.H. Frederik Falkenburg Aachen author as filed: Falkenburg, J.H. Frederik
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden
- 아카데미슈 지켄후이스 라이덴 (에이치.오.디.엔. 룸씨)
Cited papers 0 in the database
Non-patent literature as cited (2)
- - Smith, S et al., Changing the peptide specificity of a human T-cell receptor by directed evolution, 2014, Nature Comms, 5:5233 (Year: 2014)
- - Sundberg, E. Structural basis of antibody-antigen interaction, 2009, Epitope mapping protocols, Methods in Molecular Biology 524, Humana Press, Pp. 23-37. (Year: 2009)