ANTIBIOTIC COMPOUNDS
Abstract
[0001] Provided herein are lipidated glycopeptide compounds of formula (I); or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof. R1 is a lipid, R2 is -H or a lipid, and R3 and R4 are as defined herein. These compounds have antibiotic activity. Also provided are formulations comprising such compounds; as well as such compounds or formulations for use as a medicament. The compounds and formulations may also be used in the treatment of bacterial infection. [0002] L'invention concerne des composés glycopeptidiques lipidés de formule (I) ; ou un sel, un stéréoisomère, un solvate ou un promédicament pharmaceutiquement acceptable de ceux-ci. R1 est un lipide, R2 représente -H ou un lipide, et R3 et R4 sont tels que définis dans la description. Ces composés ont une activité antibiotique. L'invention concerne également des formulations comprenant de tels composés ; ainsi que de tels composés ou formulations destinés à être utilisés en tant que médicament. Les composés et formulations peuvent également être utilisés dans le traitement d'une infection bactérienne.
Inventors 8
- Nathaniel I. Martin Aachen author as filed: Martin, Nathaniel I.
- Emma van Groesen Aachen author as filed: van Groesen, Emma
- Kamaleddin H. M. E. Tehrani Aachen author as filed: Tehrani, Kamaleddin H.m.e.
- Nicola Wade Aachen author as filed: Wade, Nicola
- 纳撒尼尔·i·马丁
- 卡马莱丁·h·m·e·德黑兰尼
- van Groossen, Emma
- Dehrani, Kamaladin H M E
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- UNIVERSITEIT LEIDEN GBS Leiden
- 莱顿大学
Cited papers 0 in the database
Non-patent literature as cited (6)
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